Sentences with phrase «same mutation as»

«Our approach allowed us to grow human neurons in a dish that contained the exact same mutation as the neurons in the brain of the patient,» explained first author Helen Fong, PhD, who is also a California Institute for Regenerative Medicine postdoctoral scholar.

Not exact matches

-- It requires that all hosts with this mutation that will be favorable, NOT get fossilized, as that would show that both species lived at the same time

Skin cells are easy to collect from patients and share the same genetic blueprint — and disease - causing mutations — as brain cells.

Excess expression of the sugar is caused by the same mutation that drives the growth of most DIPG tumors, known as the H3K27M mutation, the team found.

«Just as normal cells with the same genome differentiate into many different cell types, a single tumor characterized by specific genetic mutations can contain many different types of cells — stem - like and more differentiated cells — with the difference being rooted in their epigenetic information.

And some of those mutations were the same as ones found in flu viruses circulating around the world a few years later, evolutionary virologist Jesse Bloom of the Fred Hutchinson Cancer Research Center in Seattle and colleagues discovered.

If the silencing occurred in a gene responsible for suppressing tumor formation, the result would appear the same as genetic mutations that predispose people to cancer.

The researchers posit that natural selection might favor mutations that protect against worm infection and that those same mutations might inadvertently increase the risk of other diseases, such as asthma.

Demonstrating Cpf1's noticeable specificity, another research team from the same IBS Center succeeded in bringing Cpf1 RNP - mediated mutations into mouse embryos: The researchers targeted Foxn1 (a transcription factor that regulates the immune system, including the growth of skin hairs), as well as Tyrosinase (an enzyme that catalyzes the production of melanin, a natural pigment that determines the color of skin).

As a result, every cell in the iPS cell line will contain the same mitochondrial DNA mutations as that initial adult celAs a result, every cell in the iPS cell line will contain the same mitochondrial DNA mutations as that initial adult celas that initial adult cell.

This is important because the proportion in which the de novo mutation is present in a patient, as well as the type of cells in which it occurs, may not only determine the clinical outcome of a disease for the patient, but also affect the risk of the parents having another child with the same disease in future pregnancies.

By suggesting that bears undergo mutation at roughly the same rate as humans, who also may have interbred with closely related hominins like the Neandertals, the other group finds a much older lineage.

«We propose that this mechanism allows the same cell — normal or malignant — to shift between a sensitive state and a resistant state without any permanent changes in their DNA, such as genetic mutations,» says Santagata.

The Swiss researchers have demonstrated that, when EDA is malfunctioning in lizards, they fail to develop a proper scale placode, exactly as mammals or birds affected with similar mutations in that same gene can not develop proper hairs or feathers placodes.

The fat, eyeless cavefish harbor the same genetic mutation as people with an inherited form of severe diabetes and experience diabetes - like blood - sugar surges and crashes after eating, yet they are perfectly healthy, according to a study in Nature led by geneticists at Harvard Medical School.

Tsigelny added: «The clinical treatments that do not take into consideration the specific mutations in genes, but rather treat all mutations within a specific gene such as EGFR as the same, are a «hit - or - miss» game because they are based solely on observational data on how other patients previously have reacted to drug therapies.»

In a randomized, phase 2 multi-center clinical study, led by Manisha Shah, MD of The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James), investigators tested the effectiveness of the targeted therapy drug, dabrafenib (pronounced «da bRAF e nib» and marketed as Tafinlar), given alone compared with the same drug given in combination with trametinib (pronounced «tra ME ti nib,» marketed at MeKinist) to treat a subset of advanced papillary thyroid cancer patients with B - raf mutations.

But in 2010, Stephen Rossiter, an evolutionary biologist at Queen Mary, University of London, and his colleagues determined that both types of echolocating bats, as well as dolphins, had the same mutations in a particular protein called prestin, which affects the sensitivity of hearing.

In Chow's model, all glioblastomas arise as a result of the same mutations.

As a result, it has been possible to induce the same mutation in a targeted fashion in other strains of fungus.

Blocking protein production ought to have the same effect as a genetic mutation, but the fish handle the challenges differently, the researchers found.

The first written record of tomatoes — from Spain in the 1500s — confirms that this mutation, which enlarges tomatoes by producing compartments known as locules, existed back in the same yellow tomatoes that gave Italians the word pomodoro, or golden apple.

And some of those mutations were the same as ones found in flu viruses circulating around the world a few years later, evolutionary virologist Jesse Bloom of the Fred...

All of the children were discovered to carry a mutation in the CLP1 gene and displayed the same symptoms, such as brain malformations, intellectual disabilities, seizures and sensory and motor defects.

Not all are the same as the four HA mutations that made the Dutch virus contagious.

The same mutations that made the 1918 flu contagious will not apply to H5N1, as it has a different haemagglutinin.

As it turns out, the same mutations could have been found by sequencing only the protein - coding regions of the genome — called exome sequencing — for about $ 4000.

The same mutation was present in all members of the family who had Tourette but was absent in thousands of DNA samples from control subjects, who included unrelated people with similar ethnic backgrounds as well as a group of 720 Tourette patients, the researchers report today in The New England Journal of Medicine.

The Salk scientists joined forces with a Chinese team led by Ying Xu of Nanjing University to test whether mutations in the equivalent area of PER1 would have the same effect as those in PER2 that caused the sleep disorder.

Girls with a rare genetic disorder caused by mutations in a gene known as Nf1 are much more likely to lose their vision than boys with mutations in the same gene.

One situation that could meet the report's criteria would be if both parents have the same disease, such as cystic fibrosis, that is caused by carrying two copies of a mutation, the report says.

For extended modules, many different combinations of perturbed genes could incapacitate the module, as a result of which mutations in different genes will appear to lead to the same phenotype (e.g., hypertrophic cardiomyopathy).

Again they sequenced the viruses they found in the various mosquito tissues, and they identified two new mutants, both with mutations in the same lock - picking coat protein as the original Reunion mutant, results they published last year in Cell Host and Microbe.

Furthermore, the same technologies used to create genetic models of cancer show promise as gene therapies capable of repairing mutations that lead to a range of diseases.

Mutations in a gene called ASPM, for example, reduce the size of a human brain by up to 50 percent, making it about the same size as a chimpanzee's brain.

These cells, derived from the skin cells of human patients, have the same genetic makeup — including any potential disease - causing mutations — as the patient.

«At the same time, these results raise important questions as to why certain mutations impact some individuals more dramatically than others.»

By sequencing enough fragments (to obtain what genomicists refer to as depth coverage) we can statistically rule out which mutations are false and what DNA code is real — this means we sequence enough DNA to have many DNA fragments that align to the same region of the genome.

Researchers could potentially be able to get a better sense of whether a CRISPR therapy in monkeys will translate to cures for people if the animals had the same disease - causing mutations as humans.

«These mutations happened during our evolution, so it wasn't clear if a human enhancer would function the same in a chimp as it does in human cells.»

For the mutations located in the JH1 kinase domain, we took advantage of the recently solved crystal structure of the JAK1 JH1 domain to detail their localization.21 As shown in Figure 1C, D and E, from 13 JH1 - located mutations, 3 (K1026E, Y1035C and S1043I) are located in the activation loop (A-loop), 4 mutations affect the same residue (F958V, F958C, F958S, F958L) in the hinge region of the kinase domain at the entry of the ATP - binding pocket, 3 others (D895H, E897K and T901R) are located at the top of the kinase domain in the loop formed between two antiparallel β - strands (β2 and β3) and one mutation affects the loop formed between the β - strand - 3 (β3) and the αC helix of the JH1 domain (L910Q).

Thus, identifying one of these common alleles would not have the same implications for medical management as would finding a pathogenic mutation in BRCA1 or BRCA2.

But new findings from the PREDICT - HD study suggest that the brains of men with the HD might never reach the same size as the brains of people without the mutation during development.

The RECIPIENT (i) shall register the alleles carried by mice with a new mutation engineered from the MATERIAL with Mouse Genome Informatics (MGI), and (ii) is requested to submit breeding pairs to a public repository for cryopreservation and distribution to third parties for non-commercial purposes on terms substantially the same as these Conditions of Use.

The challenge is that these mutations are «personal» to the tumor and patient; i.e., not all types of breast cancer carry the same set of mutations, and as a result, different patients have a different, personal set of mutations.

He gives as an example the fact that nearly 50 % of people of Mexican heritage, and a large percentage of Caucasian and black Americans all have some kind of MTHFR mutation that results in neural tube defects, but people of Italian descent living in Southern Italy who have these same mutations do not have the problems with neural tube defects simply because their lifestyle and environment make up for their genes.

More experienced surgeons were less likely to overreact, but even one out of four doctors in that group said they would treat uncertain results the same as a BRCA mutation.

Kirlee, as a supposed distantly related cat with the same spontaneous genetic mutation, would be a good outcross.

This research benefits humans too, because the genes involved in cancer are sometimes the same in dogs as in people, but the mutations can be more difficult to discover in people.

These documents were written about Doberman Pinchers, but as the other breeds above have the same mutation, the molecular biology and clinical manifestations will be the same in these breeds and therefore these documents apply to the other breeds as well.