Carter's recent experimental studies showed that the two small enzyme ancestors of these two families were encoded by opposite, complementary strands of
the same small gene.
Not exact matches
Intriguingly, DNA in many of the placenta samples has the
same imprinting abnormality seen in Silver - Russell, but a dampened down version of it — perhaps a
smaller stretch of the
gene is affected, or
gene expression is less abnormal.
The genome shows that octopuses have the
same small repertoire of neurotransmission
genes as lower mollusks.
They discovered that the
smallest breeds, like Chihuahuas, all had the
same gene variant that would make them
small.
Meanwhile, a second,
smaller team led by Richard Fishel at the University of Vermont and Richard Kolodner at the Dana - Farber Cancer Institute in Boston was closing in on the
same gene, using a more traditional strategy.
Upon sequencing the DNA, they found that DNA fragments containing mutated
genes — markers of tumors — were typically
smaller than healthy versions of the
gene from within the
same patient.
The researchers considered two possible explanations: Disease suppression might be the result of one or two additional substitutions on the
same gene that buffer the harmful effect of the mutation; or suppression may be caused by numerous
small substitutions throughout the genome that form an aggregate «shield.»
«People with the three
gene versions believed to encourage depression had a
smaller hippocampus than those with fewer or none of these
gene versions, even though they had the
same number of stressful life events,» says study leader Lukas Pezawas, describing the results.
They found 10 microRNAs —
small pieces of RNA that regulate
gene expression — that were the
same in all three species.
«Because the primary
Small Intestine Chip recapitulates the physical microenvironment that cells experience inside the human body, such as fluid flow and cyclic peristalsis - like stretching motions, it exhibits a genome - wide
gene expression profile that comes closer to its in vivo counterpart than that of the
same intestinal cells grown as 3D organoids,» said first - author Magdalena Kasendra, Ph.D., a former Postdoctoral Fellow on Ingber's team and now Principal Scientist at Emulate, Inc. in Boston.
Even though we all have the
same genes, there are
small variations that can influence
gene activity.
Unlike typical eukaryotic organisms, Tetrahymena has two nuclei — a micronucleus that contains normal chromosomes and a macronucleus whose chromosomes are fragmented into thousands of
small pieces of DNA that all encode the
same ribosomal RNA
gene.
Leaving aside the fact that none of these folks look like they belong in the
same gene pool (and The Wire has a funny article about how only one of the actors in the film is actually Jewish), the premise has promise, since forcing the members of a dysfunctional family (and there is much «dys» here) to spend time in a
small space could lead to some funny results.
First it will be necessary to formally exclude the COMMD1
gene by sequencing all of COMMD1 in a
small number of affected dogs that are known to not carry the COMMD1 deletion to ensure there is not a second mutation in the
same gene.
Whilst some of the lost alleles may be deleterious versions of
genes, the process may at the
same time increase the proportion of other, mildly deleterious alleles, in the
small gene pool, and thus increase the incidence of some diseases.