They do, however, play a key role in helping to boost the anti-tumor immune response by: (1) expanding the number and improving the function of existing CTLs that are specific to
the same tumor antigen; and (2) providing help to other immune cells, including B lymphocytes that are precursors to antibodies and natural killer (NK) cells that are also important in the overall anti-tumor immune response.
Not exact matches
Compared to a bolus injection containing the
same drugs and
antigens (but no scaffold), the 3D vaccine was more effective at preventing
tumor growth, with 90 % of mice receiving the 3D vaccine still alive at 30 days compared with only 60 % of mice given the bolus injection.
Cancerous
tumors and embryonic tissues have been found to share many of the
same antigens, which are detected by the immune system through antibodies.
However, higher affinity anti-cancer antibodies would also increase adverse side effects; they more effectively attack both the
tumor and other tissues that express the
same antigen.