Now, researchers at the University of Cambridge have used fluorescent markers to track cell development in the embryo of a cartilaginous fish — a little skate in this case — and found that these thorny scales are in fact created from
the same type of cells as teeth: neural crest cells.
The study examined nanoparticle entry into endothelial cells and macrophages for the in vitro study, and
the same type of cells from the lung, heart and bone marrow for the in vivo component.
Not exact matches
Embryonic stem
cells are scientifically and medically interesting because they are «pluripotent» (capable
of generating many
cell types), but they are not the
same as totipotent single -
cell embryos.
These
same cells as part
of my hand, however, can serve as instrumentalities accomplishing the aims
of my mind, such as the
typing of this chapter.
A
type of «virgin birth» stem
cell could be as powerful as embryonic stem
cells but without the
same ethical objections, and are being tested for Parkinson ’s
«What this research shows is that they're using the
same cell types with the
same kinds
of connections we see in the neocortex, but with a very different kind
of organization.»
The study, published in Nature Communications, builds on previous observations from the
same team who found that a specific
type of cells regulate antibody production.
«Each area
of the brain is different with distinct
cell types and connectivity, so if we can confirm that one area
of circuitry is more involved in a particular symptom than another, we may eventually be able to treat a depression patient more efficiently than treating everyone the
same way.»
Since the cancer
cells in both
types of tumors were the
same, the researchers compared the noncancerous
cells present in the induced and transplanted tumors to explore what might be causing the T
cell apoptosis.
Richard Bennett
of Brown University in Providence, Rhode Island, and his colleagues mixed the two
types and saw matings between
same - sex
cells, but only a few (Nature, DOI: 10.1038 / nature08252).
Different responses
of male and female
cells to the exact
same type and concentration
of nanoparticles is the latest overlooked factor we have found.»
«Just as normal
cells with the
same genome differentiate into many different
cell types, a single tumor characterized by specific genetic mutations can contain many different
types of cells — stem - like and more differentiated
cells — with the difference being rooted in their epigenetic information.
Although the face and heart don't end up so close together, they arise from the
same type of precursor
cells called neural crest
cells.
The
cells we have studied control the blink reflex, but there are many
cells of the
same type that control entirely different processes.
«Different
types of cancer
cells with different strengths and weaknesses are both present in the tumor at the
same time and can work together to spread faster and more efficiently.
One way to get many
types of cells or proteins from the
same genetic starting material is by mixing and matching different parts
of one gene to produce multiple gene readouts, a phenomenon known as alternative splicing.
In order to isolate the 3D structure
of the chromosome during metaphase, the authors used a combination
of chromosome conformation capture technologies (3C, 5C and Hi - C) developed by the Dekker lab over the last decade to map the points
of contact along the mitotic chromosome in different
cell types synchronized to divide at the
same time.
The LPA receptor is expressed in the brain
of human fetuses, just as in mice, and in the
same types of neural progenitor
cells.
This is important because the proportion in which the de novo mutation is present in a patient, as well as the
type of cells in which it occurs, may not only determine the clinical outcome
of a disease for the patient, but also affect the risk
of the parents having another child with the
same disease in future pregnancies.
For each patient, the suitable combination treatment could then be designed, which, in the first step, would turn the variety
of different tumor
cells into a mass
of cancer
cells of the
same type.
Typically,
cells of the
same type have matching patterns
of gene activity — many
of the
same genes are turned off or on in all
cells.
The
same compound promotes the growth
of tooth tissue called dentine — a protective material between the sensitive pulp inside a tooth and the enamel on its surface — so Cohen believes that the
type of tissue formed partly depends on the neighbouring
cells.
The flexible wires assume the
same basic arrangement as a common
type of rooftop solar
cell, which contains a negatively charged layer, a positively charged layer and a neutral material sandwiched between them.
In a previous related study published in the Journal
of Materials Science: Materials in Medicine, the
same team
of NTU scientists found that fish scale - derived collagen would induce human umbilical vein endothelial
cells to express 2.5 times more
of a specific
type of collagen responsible for blood vessel formation, as compared to endothelial
cells cultured on bovine collagen.
«This is a major breakthrough and a beautiful example
of convergent evolution where vertebrates at least five times have independently evolved» this ability «by modifying different
cell types to serve the
same function.»
The researchers show that
cells of the
same type take up different amounts
of viral DNA into their nucleus.
In an experimental setup that allowed the two
types of cells to bathe in the
same fluid without coming into physical contact, retinal neurons in a bath with hUTCs formed new connections between neurons called synapses, and they sprouted new «neurites» — tiny branches that lead to additional connections.
Previous studies showed that
cells which express the
same type of cadherin interact with each other, but
cells with different
types of cadherins remain separate.
All
cells in tissues adhere to each other using molecules called cadherins which interact and connect
cells of the
same type together.
The
same area has a known role in the development
of T -
cells, a key
type of immune
cell.
The researchers discovered that FT was also produced in the
same type of companion
cells in the phloem
of Maryland Mammoth tobacco.
Researchers do not know if the
same thing would work for other
types of cancer or cancer
cells lodged in other body organs.
For the first time ever, we could make a really comprehensive comparison
of individual normal and tumour
cells from the exact
same type of tissue, taken at the
same time, from the
same person, and see how the cancer had developed.»
All formed the
same types of stem
cells, which give rise to «progenitor»
cells that, in turn, divide into neurons and eventually organize themselves in six layers
of brain tissue.
The specific pattern
of epigenetic marks in a
cell type specifies identity and this epigenetic control is vital to what makes our
cells different, for example a skin
cell from a liver
cell, when they all contain the
same genetic instructions.
These are the
same T
cell genes inhibited by digoxin, and since replication
of integrated HIV - 1 requires transcription
of nearby genes, this provides an explanation for why wild
type HIV - 1 is more susceptible to digoxin: digoxin represses the genes that the virus more frequently targets for integration.
Researchers are trying to figure out how a plant or animal makes different
cell types from the
same set
of genetic instructions.
Led by researchers at Duke University, the study offers clues to a longstanding question in developmental biology, namely how plants and animals make so many
types of cells from the
same set
of instructions.
In that case, the genetic information within the chromosome copies remains the
same, but the
type of cell, or «
cell fate,» is different.
And that differentiation could provide a structural basis to help explain how
cells with the
same overall genome nonetheless can differentiate into hundreds
of different
cell types.
By comparing hippocampal and cortical neurons in mono - culture (with other
cells of the
same type) and in co-culture (both
cell types deposited within one device), the research showed that some features from hippocampal
cells, like the percentage
of action potential spikes found in bursts, were significantly higher when cultured together with cortical
cells.
Because every
cell in an organism contains the
same DNA, epigenetic marks help it find the right form for the
type of cell it inhabits.
Looking for immune abnormalities throughout the lifespan
of the mice, the group found that most immune system components stayed the
same in number, but a
type of brain - resident immune
cells called microglia that are known first responders to infection begin to divide and change early in the disease.
Neil Johnson's lab at the Fox Chase Cancer Center examined treatment resistance in breast cancer
cells expressing the
same BRCA1185delAG mutation and determined that the RING - deficient BRCA1 protein was also responsible for loss
of sensitivity to certain
types of cancer treatments.
Additionally, when the
same type of mice on the
same diet for 45 weeks, at which point they would have already developed HCC, showed no signs
of HCC after treatment with AIM, indicating that cancerous
cells were being destroyed.
Furthermore, stem -
cell lines from mice begin to lose their ability to produce many
types of cells after as few as 20 generations, and researchers assume the
same will prove true for stem
cells from humans.
Professor Wolf Reik, Head
of the Epigenetics Laboratory at the Babraham Institute and co-lead scientist on this research, said: «Transcription in individual
cells can vary between
cell types but also between
cells of the
same type.
Using tissue culture models
of cartilage and the meniscus, Levenston's team stresses the
cells and tissues and studies what happens to them structurally and biochemically — for example, whether different genes are expressed, whether metabolism changes, or whether different
types of cartilage
cells respond differently to the
same stress.
Around the
same time, Irvine's lab developed a new
type of T
cell vaccine that hitches a ride to the lymph nodes by latching on to the protein albumin, found in the bloodstream.
The resulting fragments attract several
types of immune
cells, which led pulmonologist Steven Shapiro
of Washington University in St. Louis to suspect that the fragments might also attract more
of the
same kind
of macrophages that started destroying elastin in the first place.