Sentences with phrase «same type of mutation»

Everyone with Huntington's disease has inherited the same type of mutation from their mother or father, an extra-long repetitive stretch of the sequence C - A-G in their HD gene.

When a member of Rozen's team spotted the same type of mutation in liver cancer, the group wondered if plants that contain aristolochic acid might increase a person's risk of developing the disease.

Not exact matches

«Just as normal cells with the same genome differentiate into many different cell types, a single tumor characterized by specific genetic mutations can contain many different types of cells — stem - like and more differentiated cells — with the difference being rooted in their epigenetic information.

This is important because the proportion in which the de novo mutation is present in a patient, as well as the type of cells in which it occurs, may not only determine the clinical outcome of a disease for the patient, but also affect the risk of the parents having another child with the same disease in future pregnancies.

«We call this type of mutation a complex indel because insertion and deletion is happening at the same time, in the same genomic location,» Ding said.

But in 2010, Stephen Rossiter, an evolutionary biologist at Queen Mary, University of London, and his colleagues determined that both types of echolocating bats, as well as dolphins, had the same mutations in a particular protein called prestin, which affects the sensitivity of hearing.

With the help of modern genetic technology and the resources of the International Rice GeneBank, which contains more than 112,000 different types of rice, evolutionary biologist Kenneth Olsen, PhD, associate professor of biology in Arts & Sciences at Washington University in St. Louis, has been able to look back in time and ask whether the same mutations underlay the emergence of the same traits in both cultivated and weedy rice.

This finding provides an explanation for how the same cancer - causing mutation can give rise to different types of brain malignancies.

Neil Johnson's lab at the Fox Chase Cancer Center examined treatment resistance in breast cancer cells expressing the same BRCA1185delAG mutation and determined that the RING - deficient BRCA1 protein was also responsible for loss of sensitivity to certain types of cancer treatments.

Both teams found that mutations to the same gene can also cause a common type of dementia called frontotemporal dementia (FTD).

Sometimes, two patients with the same type of cancer may be dealt different prognoses depending on their genetic mutations.

By assessing the incidence of a particular mutation or the frequency at which certain genes / pathways are altered across multiple patients (of the same tumor type), it should be possible to identify key mutations.

The challenge is that these mutations are «personal» to the tumor and patient; i.e., not all types of breast cancer carry the same set of mutations, and as a result, different patients have a different, personal set of mutations.

The Cancer Gene Census (CGC) database contains 547 such gene across various cancer types.5 Remarkably, few driver genes having specific point mutations appear to be sufficient to rewire signalling networks in cancer, 1 which at the same time shows that — at least from the mutational side — cancer does not consist of an «infinite» number of different diseases, and in many cases treatment options targeted against driver genes might be transferred from one case to the next.