To verify these results, the researchers also used mice with APC deleted by traditional methods, and found
the same types of tumors.
Not exact matches
Since the cancer cells in both
types of tumors were the
same, the researchers compared the noncancerous cells present in the induced and transplanted
tumors to explore what might be causing the T cell apoptosis.
«Just as normal cells with the
same genome differentiate into many different cell
types, a single
tumor characterized by specific genetic mutations can contain many different
types of cells — stem - like and more differentiated cells — with the difference being rooted in their epigenetic information.
«Different
types of cancer cells with different strengths and weaknesses are both present in the
tumor at the
same time and can work together to spread faster and more efficiently.
The findings also have potential uses for most other
types of solid
tumors, including those affecting the lungs and ovaries, because the
same protein and enzyme are involved, François said.
For each patient, the suitable combination treatment could then be designed, which, in the first step, would turn the variety
of different
tumor cells into a mass
of cancer cells
of the
same type.
If enacted, such a regulatory scheme could conceivably speed along clinical trials because it would allow investigators to draw from a large pool
of people with diverse
tumors that act along the
same pathway instead
of culling thousands
of people with the
same official cancer
type.
Morrison notes that
tumor growth differs even among patients with the
same type of cancer.
This
same feature,
tumor heterogeneity, may reduce the ability to identify critical gene expression changes when comparing mean gene expression in adjacent
tumor and normal tissues, as
tumors of the
same type may have different sets
of genes differentially expressed.
In the
same opening plenary session, George Coukos, M.D, Ph.D.,
of Ludwig Cancer Research and the University Hospital
of Lausanne, discussed some cutting - edge insights into ovarian cancer, a
tumor type that's typically resistant to immunotherapy.
A major new insight is the realization that different
tumors of the
same type may rely on entirely different
tumor stem cell populations.
At the molecular level,
tumors from various patients can often be quite different from each other, even though they belong to the
same type of cancer.
It is well established that
tumors, even those
of the
same type, exhibit differences in genetics and morphology.
By assessing the incidence
of a particular mutation or the frequency at which certain genes / pathways are altered across multiple patients (
of the
same tumor type), it should be possible to identify key mutations.
The metastatic
tumor is the
same type of cancer as the primary
tumor.
The challenge is that these mutations are «personal» to the
tumor and patient; i.e., not all
types of breast cancer carry the
same set
of mutations, and as a result, different patients have a different, personal set
of mutations.
Findings published in the Journal
of the National Cancer Institute show that immune cells do not respond the
same way to all
tumor types.
These
same techniques also work for other
types of cancerous
tumors that release these markers.
The primary finding
of the research was that yeast with high levels
of sugar were found to overstimulate the
same types of proteins that are commonly mutated inside human
tumors.
Complete removal
of some
types of tumors, such as sarcomas, can be difficult resulting in the
tumor returning to the
same area.
Actually, it looks like a
tumor, but it's where the worm finally landed, and it doesn't create the
same type of disease in the heart, but it does create a very bad illness in cats.
The
same can not be said for another
type of brain
tumor called a glioma, which develops in a deeper and sometimes surgically inaccessible area
of a cat's brain.
Cancers in dogs, such as bone cancer, lymphoma and many other
types of tumors, are almost identical to those
same kinds found in humans and they tend to develop faster and run their course quicker, so it's an ideal way to see if a certain therapy will work.