In the world of vaccine development, 3 1/2 months from design to injection is «warp speed,»
says vaccine researcher Nelson Michael of the Walter Reed Army Institute of Research in Silver Spring, Md..
Not exact matches
Researchers have developed a
vaccine that works in mice and rats, but scientists
say this
vaccine is still in the early stages.
«If they could figure out a way to streamline, it would be a lot better,»
said Kim Janda, a professor of chemistry at the Scripps Research Institute in La Jolla, California, who leads a team of
researchers developing a
vaccine that would prevent fentanyl overdoses by keeping the drug from reaching the brain.
There may also be other applications from this work, they
say:
Researchers could similarly take other viruses apart in the lab, scour them for important mutations and create
vaccines against a plethora of other infections.
The message that the
vaccine prevents cancer isn't getting out there,
researchers say.
«HPV
vaccine, riskier sexual activity not linked, Canadian
researchers say.»
The
researchers say public health authorities must address people's concerns and debunk unscientific claims if they are to ensure a
vaccine is effective.
«Although HPV
vaccine has been around for more than a decade, the uptake of the
vaccine has been less than ideal in many places, including in high - resource countries such as the United States,»
said Silvina Arrossi, PhD, co-chair of the Expert Panel that developed the guideline and an official and
researcher at the Instituto Nacional del Cancer in Buenos Aires, Argentina.
«Funders don't control the composition of the committee, and they don't meet with the committee,»
says Harvard public - health
researcher Marie McCormick, who chaired the IOM
vaccine - safety committee in question.
If
researchers could induce antibodies with long HCDR3s in humans, «then that could be the basis of getting a
vaccine to work,» Smider
says.
«In the last few years, we've decided that it's probably not a good idea to produce [
vaccines] in food products,»
says Hugh Mason, an Arizona State University
vaccine researcher who helped develop the first edible
vaccine.
Studies that compare flu alterations in multiple people won't immediately tell
researchers how to design
vaccines, she
says, but could point to parts of the virus for further investigation.
The
researchers said it was important to test their candidate
vaccines on the Makona strain to ensure that even small differences between the strains didn't impact the effectiveness of the
vaccine.
The genetic code also holds clues to Chlamydia's surface proteins, which Stephens
says should give
researchers new targets for
vaccines, diagnostic tests, and drugs.
Many Ebola
researchers say they, too, would eagerly try the antibodies — or one of the promising candidate drugs, or an experimental Ebola
vaccine.
Crotty
says the ability to measure Tfh cells in the blood will assist AIDS
vaccine researchers by serving as an indicator of antibody response.
And questions abound, many from
researchers and developers who
say they need recent virus samples to produce more efficient
vaccines.
And no drug or
vaccine is going to work once patients are very ill,
says Ebola
researcher Thomas Geisbert of the University of Texas Medical Branch in Galveston; if patients seek care too late, that could create the mistaken impression that the interventions are useless.
The same strategy might aid efforts to design
vaccines against other viruses,
researchers said.
Researchers must be prepared to construct new
vaccines to deal with emerging new strains,
says Mooi.
But other diarrhea
researchers say that the
vaccine's effectiveness in Venezuela doesn't mean that it will work everywhere.
Johns Hopkins Bloomberg School of Public Health
researchers say a new candidate
vaccine against respiratory syncytial virus (RSV) made with a weakened version of the virus shows great promise at fighting the disease, the leading cause of hospitalization for children under the age of one in the U.S.
A new type of easily customizable
vaccine can be manufactured in one week, allowing it to be rapidly deployed in response to disease outbreaks,
say researchers.
Dr Welaga
says that
researchers should consider testing the effect of measles
vaccines and other routine
vaccines on all - cause mortality in randomized trials.
With this approach if validated for other
vaccines, we only need to wait for a week,»
says researcher Ali Harandi, who heads the participation of Sahlgrenska Academy and University of Gothenburg in the project.
These findings could lead to the first broadly effective ebolavirus therapies and
vaccines,
say researchers.
«Dengue
vaccine could increase or worsen dengue in some settings:
Researchers say health officials must be careful about where
vaccine is used.»
A new HCV infection is effectively treated with direct - acting antiviral drugs, but the
researchers say a preventive
vaccine is needed to control what they call an HCV pandemic because as many as 50 percent of people infected are unaware that they carry the virus, putting others at risk of infection.
Of more than 50 therapeutic
vaccine trials so far, this is the first one that has bolstered the immune system in a «meaningful» way,
says Steven Deeks, an HIV / AIDS clinician and
researcher at the University of California, San Francisco, who is «cautiously optimistic» that the data will inspire others to study the approach.
Frieden
said the halt has raised concerns from
researchers working on drug - resistant tuberculosis, the Ebola outbreak in Africa, and preparations for next season's influenza
vaccine.
«That is super solid protection,»
says CJ Peters, a
vaccine researcher at University of Texas, Galveston.
Also, he
says, the study shows that high - risk groups, such as
researchers and lab technicians working with West Nile, should consider getting a JE shot as long as there's no specific West Nile
vaccine.
Sanaria's
vaccine aims for 90 % protection or even higher,
says CEO Stephen Hoffman, a former U.S. Navy
researcher who started the company in his kitchen 8 years ago.
This is why it is so difficult for humans to mount an effective immune response and why it is challenging for
researchers to develop
vaccines targeting the HIV envelope proteins,» Dr. Blanchard
says.
Adrian Hill, a
vaccine researcher at the University of Oxford in the United Kingdom,
says the experiments support the idea that
vaccines helped make Marek's disease deadlier, but don't prove it.
The
vaccine also has potential to be administered to developing chicks in eggs, resulting in offspring being automatically vaccinated for the diseases,
said Wenjun Ma, Kansas State University assistant professor of diagnostic medicine and pathobiology and one of the
researchers involved.
The results are «very encouraging,»
says Mariano Esteban, a poxvirus
researcher at the Universidad Autónoma in Madrid, Spain, adding that they could prelude a safer generation of smallpox
vaccines for humans to replace the old standbys from the smallpox eradication era.
In the real world, a field like the AIDS
vaccine one has so much failure that when
researchers see positive data they
say, Eureka!
The studies support the concept of using natural exposure in combination with malaria - fighting drugs to help people build up protection against disease,
says malaria
vaccine researcher Robert Sauerwein of the Radboud University Nijmegen Medical Center in the Netherlands.
Using both DNA and protein
vaccines resulted in more diverse antibodies, the
researchers say.
The
vaccine is a «very novel approach for the treatment of obesity,»
says Matthias Tschöp, an obesity
researcher at the University of Cincinnati in Ohio.
Doctors could potentially use the pneumonia prediction score to encourage older adults to get the pneumococcal
vaccine that protects against pneumonia, as well as to counsel at - risk individuals about positive behavioral changes such as quitting smoking,
said the
researchers.
The
vaccine, a DNA
vaccine, is safer and more effective against Zika virus and could offer more affordable long - term protection,
researchers said.
Only one
vaccine has been licensed, and neither it nor any others in development today will be 100 percent effective against malaria infection,
said lead
researcher José A. Stoute, associate professor of medicine and microbiology and immunology.
The
researchers say the results warrant further development of neoantigen
vaccines, both alone and in combination with other immunotherapy weapons such as checkpoint inhibitors.
Meanwhile,
researchers are already finding new ways to enhance the
vaccine's effectiveness, he
said.
«When the SSGCID solves protein structures, it lays the foundation for
researchers at CID Research and around the world to find new drugs, therapies and
vaccine candidates for diseases that kill thousands each year,»
said Myler.
Whitehead and the other
researchers said that in the case of dengue, the testing was warranted because they knew that the
vaccine appeared to be effective at preventing dengue 1, 3 and 4 viruses through previous testing but needed to learn more about its impact on dengue 2 before proceeding to larger trials that could take three to 10 years and cost tens of millions of dollars.
Leaders of several of the nation's top science organizations
say they've been shunned by the Trump administration and are alarmed by signs that the administration will muzzle government
researchers and reject the scientific evidence that informs such critical issues as
vaccine safety and climate change.
There is no drug to treat Zika or a
vaccine to prevent it, although Fauci
said researchers are working on the latter.