Sentences with phrase «scale functional studies»

Not exact matches

Validating this original concept, we previously demonstrated that PGD - derived hES cells and their derivatives, which express the causal mutation implicated in the Myotonic Dystrophy type 1 (DM1), offer pertinent disease - cell models, applicable for a wide systemic mechanistic analysis ranging from functional studies at the cellular level to a large - scale drug screening.

The perspectives are to upgrade the scale of the functional genomic screen to a genome wide study to get an highlight of all of the biological networks relevant to be targeted for DM1.

The ICS is a large - scale facility open to the community that ensures the generation of mouse models à la carte, the validation of genetic models, the expansion and preservation and distribution of models with the housing department, and offers in its phenotyping department a series of standardized functional analysis of mouse models that can be performed in a comprehensive pipeline or on demand, as well as for more specialized studies, that cover the major functions and key physiological systems.

Ageing research and more generally the study of the functional basis of human diseases profit enormously from the large - scale approaches and resources in mouse functional genomics: systematic targeted mutation of the mouse genome, systemic phenotyping in mouse clinics, and the archiving and distribution of the mouse resources in public repositories.

The DOMINO group's futility study enrolled 114 patients with mild to moderate HD, measured using the Total Functional Capacity (TFC), a widely used scale of the effect of HD symptoms on a person's ability to function in daily life.

Practical aspects of conducting large - scale functional magnetic resonance imaging studies in children

Four dimensions of health - related quality of life were measured: general health (self - reported general health), physical health (absence or presence of functional limitations and illness symptoms), emotional health (the Center for Epidemiologic Studies Depression Scale and Rosenberg's self - esteem scale), and a school and social functioning sScale and Rosenberg's self - esteem scale), and a school and social functioning sscale), and a school and social functioning scalescale.