Sentences with phrase «scale mouse studies»

Future pre-clinical work will require additional optimization, large - scale mouse studies and rigorous safety analysis, the researchers emphasize.

Not exact matches

Our study has been made possible by leveraging findings from a large - scale analysis in mice to recover mutations causing congenital heart defects.

A large - scale study of two strains of lab mouse by Viola André, Martin Hrabé de Angelis and co-authors shows that the inclusion of nesting material and shelters as environmental enrichment does not impair the scientific assessment of a battery of 164 physiological parameters in mice.

The new study compares genome - scale data of 21 mice that originated in 15 different locations in Europe and Africa.

The ICS is a large - scale facility open to the community that ensures the generation of mouse models à la carte, the validation of genetic models, the expansion and preservation and distribution of models with the housing department, and offers in its phenotyping department a series of standardized functional analysis of mouse models that can be performed in a comprehensive pipeline or on demand, as well as for more specialized studies, that cover the major functions and key physiological systems.

Ageing research and more generally the study of the functional basis of human diseases profit enormously from the large - scale approaches and resources in mouse functional genomics: systematic targeted mutation of the mouse genome, systemic phenotyping in mouse clinics, and the archiving and distribution of the mouse resources in public repositories.

A large - scale study, published in Wellcome Open Research and which passed peer review today, has shown that inactivating the same gene in mouse embryos...