Large -
scale sequencing efforts like the 1,000 Genomes Project and The Cancer Genome Atlas now consider BAM the standard format for data exchange.
The reasons for this are complex, and not the focus of this post, but I think we can all agree that it's vital to seek out and include samples from diverse ancestries as large -
scale sequencing efforts move forward.
In the meantime, we are in the midst of large -
scale sequencing efforts for the Centers for Complex Disease Genomics (CCDG), Alzheimers Disease Sequencing Project (ADSP), and Gabriella Miller Kids First (GMKF) initiatives.
Then we were off and running for CCDG and another large -
scale sequencing effort funded under the Gabriella Miller Kids First (GMKF) program.
Not exact matches
As large -
scale genome
sequencing projects, such as the Human Genome Project, near completion, the research community's focus is shifting toward
efforts to determine functional information about these
sequenced genes.
Large -
scale genome
sequencing efforts, like the Human Microbiome Project, have focused on the community of microorganisms that live in the human gut.
Also today, NHGRI and the National Cancer Institute (NCI), both part of the National Institutes of Health (NIH), announced that all three
sequencing centers will devote a significant part of their
efforts to The Cancer Genome Atlas (TCGA) Pilot Project, which is testing the feasibility of a large -
scale, systematic approach to identify important genomic changes involved in cancer.
Large -
scale cancer
sequencing efforts such as TCGA and ICGC have catalogued somatic mutations in a variety of common cancer types.
Now, a greater
effort to understand its ecological and population history has been made possible by the first, whole -
scale genome
sequencing efforts of 57 platypuses across Eastern Australia and Tasmania.
Sparked from the
efforts of the T2D - GENES Consortium (Type 2 Diabetes Genetic Exploration by Next - generation
sequencing in multi-Ethnic Samples; T2D - GENES) to aggregate and share results from large -
scale T2D
sequence and genotype datasets, the prototype T2D KP was built with seed funding from the NIDDK via the T2D - GENES Consortium and the Slim Initiative for Genomic Medicine in the Americas for T2D (SIGMA T2D).
In the new study, the lab has conducted the first large -
scale whole genome
sequencing study of asthma drug response in African Americans and Latino children in an
effort to pin down the genetic factors contributing to reduced albuterol response more precisely than possible in previous association studies.
Topics that will be explored include: • Cellular and developmental origins of pediatric cancer • Key findings of pan-cancer analysis
efforts • Computational pipelines to analyze large -
scale sequencing data • Opportunities for leveraging existing cancer genomics datasets • Strategies for integrative analysis of germline and somatic variants • Correlation of germline / somatic variation to clinical features such as tumor subtype.
TCGA, launched in 2005, is a comprehensive and coordinated
effort to accelerate the understanding of the molecular basis of cancer through the application of genome analysis technologies, including large -
scale genome
sequencing.
He directs a Genome Data Analysis Center as part of The Cancer Genome Atlas (TCGA) project, a comprehensive and coordinated
effort to accelerate our understanding of the molecular basis of cancer through the application of genome analysis technologies, including large -
scale genome
sequencing.
Of course with enough time, money and
effort most DNA
sequences can eventually be built; de novo designed mammalian genome -
scale synthesis however will require a drop in cost by orders of magnitude together with technology improvements to enable DNA synthesis without restrictions on
sequence composition.
But during the aerial «dogfight»
sequences, the film is something else again: a grand -
scale spectacular, the likes of which has never been duplicated, not even by more expensive
efforts like Hell's Angels (1930) and The Blue Max (1965).
Develop a clear plan to
sequence and
scale up the state's
efforts, and plan ahead for what will become of schools when they do turn around.