Sentences with phrase «scale trials for»

Another major pharma player, Roche, canceled its BACE1 research back in 2013, but several large - scale trials for BACE1 inhibitors are still currently in development or underway.

In another small - scale trial for multiple sclerosis, treatment appeared to reverse the disease's progression and its associated disability, a further historic first.

Not exact matches

While the new mid-stage study results from DNDi were impressive (they showed cure rates of 96 % to 97 % even for the sickest patients and those with liver scarring), more late - stage trials will be necessary before the drug is available on a large scale in the developing world.

If large - scale trials can replicate safety and efficacy results, the drug could be approved for legal use by 2021.

Our highly skilled technicians combined with our laboratory - scale processing equipment reduce the need for large plant trials and accelerates the development of your product and speed to market distribution.

«Protein in breast milk reduces infection risk in premature infants: Study shows need for large - scale trial of lactoferrin's role in immune system development.»

«Our results justify the need for a large - scale trial of lactoferrin, as well as its counterpart derived from cow milk, bovine lactoferrin.»

The Department for Work and Pensions (DWP) quietly published a large - scale trial of the scheme last year.

By late 2012, it adds, «the department had largely stopped developing systems for national roll - out and concentrated its efforts on preparing short - term solutions for the pathfinder» (the small scale trial of the system).

The drug is undergoing testing at a 3 milligram (mg) dose for long - term weight management as part of the SCALE ™ (Satiety and Clinical Adiposity — Liraglutide Evidence in Nondiabetic and Diabetic Subjects) Obesity and Prediabetes trial.

An NIH - backed vaccine is among several heading for human trials, but the timeline for large - scale deployment remains murky

This year, Rocke hopes to conduct larger - scale field trials to determine the levels of immunity required for success in a mass vaccination.

The SCALE Obesity and Prediabetes trial is continuing for two more years for the prediabetic subjects in arm 2.

The drug is not approved for weight management, according to its manufacturer, Denmark - based Novo Nordisk, which sponsored this study, called the SCALE ™ (Satiety and Clinical Adiposity - Liraglutide Evidence in Nondiabetic and Diabetic Subjects) Obesity and Prediabetes trial.

That year, Targacept reported that in phase II trials with an approved antidepressant, TC - 5214 had few side effects and produced a six - point improvement on the Hamilton rating scale for depression.

A panel of scientists said there was no scientific justification for this large - scale trial of a single product and the money has now been handed to the National Institutes of Health to compare several vaccines instead.

This vaccine has been at the heart of a controversy in the US after Congress awarded the defence department $ 20 million to test it in large - scale trials in America as an immune therapy for HIV - positive people.

«We don't know what exposure is leading to this susceptibility to dietary glutamate, but this pilot study suggests the need for a large - scale clinical trial, since dietary change could be an effective low - cost treatment option for developing countries.»

We also have a large - scale biologics manufacturing facility in Rensselaer, New York, where we produce commercial and investigational products for clinical trials, and a satellite office in Basking Ridge, New Jersey.

The controversy came to a head in March when the National Institutes of Health issued a notice of a competition soliciting participation in a large - scale clinical trial to evaluate the effectiveness of fetal surgery as a treatment for spina bifida.

For example, this could support large - scale epidemiologic studies or remote pharmacological trials,» said senior and corresponding author David L. Kaplan, Ph.D., Stern Family Professor in the Department of Biomedical Engineering at Tufts School of Engineering.

Graham looked to the Internet for treatment options and came across Duke University oncologist Keith Sullivan, who was comparing standard chemotherapy and stem cell therapy as part of a large - scale clinical trial for scleroderma.

When people with early - stage symptoms took omega - 3 supplements for three months, they had much lower rates of progression than those who did not, according to one small - scale trial.

Those encouraging findings from the small - scale pilot study formed the basis for this multi-center clinical trial led by Carley and Zee.

While a postdoctoral fellow at the Naval Medical Research Institute in Bethesda, he developed a system for large - scale efficient culture of lymphocytes that has proved to be the foundation for over 35 early phase clinical trials of adoptive immunotherapy.

«This risk scale provides an inexpensive and easy way for doctors to identify people who should be referred to more advanced testing for memory issues or may be better candidates for clinical trials,» said Petersen.

This is a very promising finding that provides an excellent basis for future larger scale trials using the intervention in very early development.»

To make up for those shortcomings, the report called for a research program, including smaller scale field trials, whose goal «should be to improve understanding of the range of climate and other environmental effects of albedo modification, as well as understanding of unintended impacts.»

Larger scale clinical trials are currently being planned to pave the way for eventual release to the market.

At the meeting, GlaxoSmithKline (GSK) of Rixensart, Belgium, which has the vaccine furthest in development, spelled out how it might scale up production in parallel with the safety and efficacy trials now under way so that the product could be ready for wider distribution by April if warranted.

In 2002, the research team for TRIGR (Trial to Reduce IDDM in the Genetically at Risk), led in the U.S. by principal investigator Dorothy Becker, M.D., professor of pediatrics at Children's Hospital and the University of Pittsburgh School of Medicine, embarked on a large - scale study of 2,159 infants with a family member affected by type 1 diabetes and with genetic risk for type 1 diabetes to find out whether delaying the exposure to complex foreign proteins such as cow's milk proteins would decrease the risk of diabetes.

Ashikaga cautions that larger - scale clinical trials are needed before the measurement can be recommended for wider use.

It worked well in a pilot test in Washington, D.C., and an international consortium has been organized for a large - scale trial in Costa Rica.

Moving forward, the NUS team intends to carry out larger scale trials to establish the full potential performance of sand for impact resistance.

If the trials are successful, they could open the way for full - scale development of the air - breathing rocket engine.

«While the results of this study are preliminary, they hold promise for enhancing and maintaining brain reserve in later life, particularly among sedentary individuals who may benefit most urgently from behavioral interventions like Experience Corps,» said Carlson, who is now leading a larger fMRI trial as part of a large - scale randomized trial of the Baltimore Experience Corps Program.

iBET's infrastructure comprises 16 laboratories fully equipped with state - of - the - art technology (70 m2 each), including a BSL2 laboratory for working with viruses; a GMP Analytical Services Unit certified by the INFARMED (the Portuguese medicines authority, EMA Portuguese branch) and by DGAV (the Portuguese veterinary authority) for quality control and batch release of human and veterinary pharmaceuticals, biopharmaceuticals as well as experimental new drugs; a GMP Mass - Spectroscopy Unit that provides state - of - the - art MS services to the scientific community and Industry; a 2600 m2 bio-pilot plant supporting production and purification of proteins ATMPs and vaccines from bench top to 300 L scale and privileged access to GeniBET Biopharmaceuticals, an iBET spin - off producing ATMPs under cGMP certification for phase I / II / III clinical trials.

Although these platforms can be used successfully for small - scale expansion of hMSCs, other platforms will be required to generate the quantity of cells required to support the increasing number of clinical trials utilizing hMSCs and the subsequent large - scale production.

This service is for the moment only available for staff at Uppsala University, during a trial period, since we wish to try this approach in a small scale to begin with.

Dr. Shoyele plans to continue the research with comprehensive toxicity tests and scaling the nanoparticle manufacturing process for clinical trials.

Also scheduled for this fall is a large - scale clinical trial of an HIV vaccine, which will be conducted in South Africa and co-funded by NIH.

They will perform preliminary studies to prepare for large - scale testing, conduct related studies to support specific trials, provide mentoring for junior faculty, and help recruit appropriate patients to Network trials, especially those expected to have a significant positive impact on cancer treatment.

Showing correlations of sensor data with existing clinical scales in a trial setting is a prerequisite for leveraging such data in clinical practice and drug development.

If successful, this method will be tested at scale by an industrial partner who will generate clinical - grade material for a Phase 1 trial at the end of this five - year grant.

They noted that the present findings warrant a confirmatory clinical trial for SMA rTMS on PD, undertaken on a larger scale.

A Clinical Core has capability to safely and efficiently distribute clinical studies of vaccine immunosafety for biomarker discovery from small intensive trials to large - scale studies of adult, paediatric and other populations.

However, with few exceptions, the stem cell and regenerative medicine industry has remained inadequately capitalized to carry out large - scale clinical trials independently, and major pharmaceutical firms have tended to show more interest in the use of hiPSCs as a source of large, pure populations of specific somatic cells for use in drug compound screening and toxicology tests, than they have in therapeutic uses of stem cells and their derivatives.

Dr. Rocke is currently leading a large - scale field trial in 8 western states of the U.S. to determine if oral vaccination through consumption of vaccine - laden baits prevents plague in wild prairie dogs, thus reducing the risk of disease for the endangered black - footed ferret, other animals, and possibly humans.

Although the swine - flu shot has successfully made it through clinical trials, has been approved by the Food and Drug Administration, and has been deemed safe for people with weakened immune systems, its large - scale distribution hasn't yet been evaluated.

We need to be spending a billion dollars for high - quality long - term big - scale randomized, controlled trials, but most of the research we do in nutrition suffers from a shoestring budget.