Sentences with phrase «scale trials from»

Not exact matches

While the new mid-stage study results from DNDi were impressive (they showed cure rates of 96 % to 97 % even for the sickest patients and those with liver scarring), more late - stage trials will be necessary before the drug is available on a large scale in the developing world.

«Our results justify the need for a large - scale trial of lactoferrin, as well as its counterpart derived from cow milk, bovine lactoferrin.»

That's because a trial like this one is almost without precedent in modern medical research: It involves giving children a vaccine that is almost certain not to benefit them, and that might harm them, all to protect other children from an unlikely scenario — a large - scale anthrax attack.

The results from the latest trials, in 2014, focused on three endpoints: sexual function index (where women answered questions about sexual experience and rated levels of sexual desire on a scale of one to five over the last 28 days), satisfied sexual events, and distress felt from a low libido.

To journey safely from this universe to another — to investigate the various options and do some trial runs — an advanced civilization will need to be able to harness energy on a scale that dwarfs anything imaginable by today's standards.

Those encouraging findings from the small - scale pilot study formed the basis for this multi-center clinical trial led by Carley and Zee.

The researchers caution that the reliable detection of small to moderate risks and benefits of drug therapies requires cogent data from large - scale randomized trials designed a priori to test the hypothesis.

Researchers from the United Kingdom undertook an open randomized controlled trial to determine if autoinflation with a nasal balloon could be used on a large scale to benefit children in primary care settings.

Male circumcision cuts the risk of HIV transmission in men by about 60 percent and should be scaled up in countries hardest hit by the epidemic, the World Health Organization (WHO) announced in March, citing compelling evidence from three large trials in Kenya, Uganda, and South Africa.

The eagerly awaited results from the world's first large - scale trial of a malaria vaccine are in, and they confirm what other, smaller studies had shown: The vaccine, called RTS, S, offers partial protection, cutting episodes of malaria in babies and toddlers in half.

«While the results of this study are preliminary, they hold promise for enhancing and maintaining brain reserve in later life, particularly among sedentary individuals who may benefit most urgently from behavioral interventions like Experience Corps,» said Carlson, who is now leading a larger fMRI trial as part of a large - scale randomized trial of the Baltimore Experience Corps Program.

iBET's infrastructure comprises 16 laboratories fully equipped with state - of - the - art technology (70 m2 each), including a BSL2 laboratory for working with viruses; a GMP Analytical Services Unit certified by the INFARMED (the Portuguese medicines authority, EMA Portuguese branch) and by DGAV (the Portuguese veterinary authority) for quality control and batch release of human and veterinary pharmaceuticals, biopharmaceuticals as well as experimental new drugs; a GMP Mass - Spectroscopy Unit that provides state - of - the - art MS services to the scientific community and Industry; a 2600 m2 bio-pilot plant supporting production and purification of proteins ATMPs and vaccines from bench top to 300 L scale and privileged access to GeniBET Biopharmaceuticals, an iBET spin - off producing ATMPs under cGMP certification for phase I / II / III clinical trials.

A Clinical Core has capability to safely and efficiently distribute clinical studies of vaccine immunosafety for biomarker discovery from small intensive trials to large - scale studies of adult, paediatric and other populations.

From our small scale trial of this (7 people), there does seem to be an effect.

We need to be spending a billion dollars for high - quality long - term big - scale randomized, controlled trials, but most of the research we do in nutrition suffers from a shoestring budget.

As expected, measurements of fatigue, soreness, and exertion on a Likert scale revealed significant differences from pre to post during each exercise trial.

Measurements of fatigue, soreness, and exertion on a Likert scale revealed significant differences from pre to post during each exercise trial.

The research presented here is the first large - scale randomized - control trial designed to measure what students learn from school tours of an art museum.

Nonetheless, seeking a universal truth, Heckman asserts that positive results from a small - scale trial, conducted half a century ago, «prove» what policymakers should do with hundreds of billions today — and never mind the political, organizational, or practical complexities of trying to replicate that success in the real world.

It was «the first large - scale randomized - control trial designed to measure what students learn from school tours of an art museum.»

«The Educational Value of Field Trips,» by Jay P. Greene, Brian Kisida, and Daniel H. Bowen, which appeared in the Winter 2014 issue of Education Next, is the first large - scale randomized - control trial designed to measure what students learn from school tours of an art museum, this one in Bentonville, AR.

A study by Jay P. Greene, Brian Kisida and Daniel H. Bowen, «The Educational Value of Field Trips,» was the first large - scale randomized - control trial designed to measure what students learn from school tours of an art museum.

New evidence has been collected from publicly funded voucher programs in Florida and Cleveland; new findings from randomized field trials conducted in New York City, Dayton, Charlotte, and Washington, D.C., are now available; and a growing body of evidence collected abroad provides a comparative perspective on the probable effects of large - scale choice initiatives.

New inroads in preventing adolescent drug use: results from a large - scale trial of project ALERT in middle schools.

The EEF is conducting a scale - up trial to see if the results from the initial study can be replicated across a larger number of schools.

Dr. O'Haire says the valuable data from the pilot study helped secure the NIH R21 grant to conduct the large - scale, clinical trial to further investigate the efficacy and role of service dogs for military veterans with PTSD and their spouses.

However, it does not end there as numerous activities are around every corner and straight such as competing in time trials from a few seconds in length through a single street for around 5 seconds or an entire route taking around 2 minutes in attempt after attempt to beat offline times or times set by players on a global scale for times and show times in road rules, alongside 400 gates and 120 billboards to smash through as well as 50 jumps to land and more besides.

The dates of the works range from the mid 1990's to 2009, with one deeply emotional large - scale work portraying O.J. Simpson's mother at his trial in 1995 and another depicting a 1990's New York City, West Village Halloween scene with yet another Marilyn reference.

The Australian Renewable Energy Agency (ARENA) is seeking expressions of interest (EOI) for projects to trial short - term forecasting from large - scale wind and solar farms across Australia.

As we move from scale economies and the innovation structures that dominated the 1990s, we are now in a period of reducing trial costs and time but increasing clinical and commercial differentiation of new compounds according to Deloitte.

From Randomized Controlled Trials to Community - Level Change: What Should be Expected When Taking Home Visiting Programs to Scale?

Another meta - analysis reached similar conclusions about the equivalence of CBT and BT1 and a recent large - scale clinical trial of BT showed that it was as effective as antidepressant medication for depression.3 While BT and CBT were equally as effective for lower - levels of depression severity, patients with severe depression specifically benefited more from BT than CBT.3 Behavioural activation, which involves graded activity and goal scheduling, is the central component of BT for depression and may be related to a more general mechanism of change that is operating in many different treatments for depression, especially CBT.

Geriatric Depression Scale Scores in a representative sample of 14 545 people aged 75 and over in the United Kingdom: results from the MRC Trial of Assessment and Management of Older People in the Community.

Information regarding the theoretical foundations of MF - PEP has been published previously.21 Pilot studies indicate that MF - PEP is associated with the following: increased knowledge of mood disorders; increased positive family interactions; increased efficacy in seeking treatment; improved coping skills; improved parental attitude toward the child and the treatment; increased social support from parents; and a trend toward increased social support from peers in children.22, 23 To assess the impact of MF - PEP on children's mood symptoms, this full - scale randomized trial was conducted.

Design, Setting, and Participants Randomized controlled trial of heterosexual and same - sex couples (n = 40 couples; n = 80 individuals) in which one partner met criteria for PTSD according to the Clinician - Administered PTSD Scale, conducted from 2008 to 2012 in a Department of Veterans Affairs outpatient hospital setting in Boston, Massachusetts, and a university - based research center in Toronto, Ontario, Canada.

A recent review offers ambiguous support for the relation between home visitation and reductions in child maltreatment.2 The findings from several large - scale home - visitation efforts have shown disappointing short - term results in reducing family violence and child maltreatment.4, 9 A 15 - year follow - up study of the Elmira trial families, however, provided the first evidence from a randomized trial for the long - term effects of home visitation on reducing child maltreatment.10 Results from the follow - up showed that nurse - visited families had half as many child maltreatment reports as families in the comparison group.

Findings From a Multiyear Scale - Up Effectiveness Trial of Open Court Reading.

Where results are reported using short ordinal scales, we will use the methods of Whitehead and Jones to produce a single OR from each trial (Whitehead 1994).

New research from around the world is emerging every week — from ecacy trials to a new emphasis on implementation studies as countries begin to scale up interventions.

In the past 45 years, hundreds of studies focusing on PMT with children with conduct problems have appeared.10 - 12, 15 - 18 Study designs have ranged from case descriptions, single - case designs, and simple pre - to post-treatment evaluations to large - scale, randomized controlled trials with various control and alternative treatment comparison conditions.

From 1999 - 2005 they conducted a large scale effectiveness trial with 700 foster families in the San Diego child welfare system.

Two studies have analysed cost effectiveness of CBT for severe health anxiety delivered in a conventional face - to - face format compared with treatment as usual using data from randomised controlled trials.8, 9 In the first study, it was found that CBT but not the control condition reduced consumption of primary and secondary healthcare contacts, but total costs were unchanged in both conditions.8 In the second study, a large - scale randomised trial, the health economic analyses showed that there were no significant differences between the two treatment conditions.9 In both of the above studies, CBT was superior in reducing health anxiety symptoms compared with treatment as usual, which means that as costs were similar across groups, CBT is likely to be the more cost - effective treatment option.

Increasingly, in complex public health evaluation research, there are questions about whether all relevant benefits can be captured in a single summary outcome measure such as QALY or unit of «effectiveness» or net benefit approach17 which is why the use of a cost - consequence analysis (CCA) framework is being recommended for such economic evaluations.18 Other outcomes from the trial such as the Parent — Infant Relationship Global Assessment Scale (an observational measure that is independently rated blind to group allocation) will be included in the CCA so that all costs and outcomes from the trial can be displayed transparently for decision - makers to consider trade - offs themselves.

Results, including the magnitude of effect sizes, are consistent with findings from a large - scale cluster - randomized trial demonstrating the effectiveness of StandUp's predecessor, Teen Choices, in preventing peer violence (Levesque et al., in press).