High PI and DBI equals short lifespan MLSP despite mitochondrial Glutathione and Thioredoxin trying its best to
scavenge membrane Hydroperoxides formation from
hydroxyl radical stealing hydrogen atom from unsaturated fatty acids (initiating lipid peroxidation propagation forming highly mutational reactive aldehydes (MDA, MDA - TBARS), alkenals (4 - HNE), methylglyoxals (creating glucosepane, MDA - Lys, CML, pentosidine, CEL, furosine from Amadori).
These free radicals (such as: superoxide,
hydroxyl radical, and peroxynitrite) are controlled by antioxidant systems and when these systems can't cope with the amount of free radicals produced these free radicals
scavenge for electrons from proteins, cell membranes, and DNA.