Curcumin exerts both direct and indirect antioxidant effects by
scavenging reactive oxygen species (ROS)(38) and inducing the expression of cytoprotective proteins in an Nrf2 - dependent way (39).
Their antioxidant and anti-inflammatory activities are largely due to their abilities to
scavenge the reactive oxygen species (ROS) and improvement of antioxidant status by attenuating the activity of NF - κB and suppressing the expression of several inflammatory cytokines and chemokines including monocyte chemotactic protein - 1 (MCP - 1), nitric oxide synthase, cyclooxygenases, lipoxygenases, cellular adhesion molecules, tumor necrosis factor and interleukins.
The resulting drop in glutathione production and intracellular glutathione concentrations compromises the mitochondria's ability to
scavenge reactive oxygen species (ROS), producing a vicious cycle that drives the progressive increase in ROS - mediated structural damage and its corollary, the progressive decline in energy production and repair that accompanies aging.
Not exact matches
Furthermore, the manganoporphyrin was stably contained within the microcapsule without release, and researchers showed that both manganoporphyrin and tannic acid were required for the synergistic
scavenging of
reactive oxygen species.
Radiation was used to generate
reactive oxygen species (free radicals) and tribulus terrestris was able to
scavenge them.