Working with this hypothesis, the researchers conducted a statistical analysis of the CX3CR1 gene in over 7000
schizophrenia and autism patients and healthy subjects, finding one mutant candidate, a single amino acid switch from alanine to threonine, as a candidate marker for prediction.
Not exact matches
The Muotri lab uses induced pluripotent stem cells from
patients with
autism and schizophrenia to look for biomarkers of these conditions.
«The interaction between the two types of neurons could also help explain the presence of seizures in
patients with
schizophrenia, dementia
and some forms of
autism.»
Altered patterns of variability were observed in the brain's default network with
schizophrenia,
autism and Attention Deficit Hyperactivity Disorder (ADHD)
patients.
The same change is seen in
patients with neuropsychiatric conditions such as
schizophrenia, Down's syndrome,
and autism,
and in people with poor impulse control.
First, an analysis of genomic data from 6,000
patients with
autism spectrum disorders, 1,000
patients with bipolar disorder,
and 2,500
patients with
schizophrenia by co-first author Pierre - Marie Martin, PhD, a postdoctoral researcher in Cheyette's lab, revealed that disruptive mutations in the main neuronal form of DIXDC1 were present about 80 percent more often in psychiatric
patients (0.9 percent had mutations) compared to healthy controls (0.5 percent had mutations).
He has developed novel cellular models of neurological diseases (
schizophrenia, MS,
autism, Alzheimer's, Parkinson's) using human induced pluripotent stem cells (iPSCs) derived from donor
patients and differentiated to specific neuronal cell types.
A 2007 study by Rzhetsky
and colleagues that applied statistical modeling methods to
patient records alone found a significant overlap between
autism,
schizophrenia,
and bipolar disorder that implied a genetic relationship.
The answer given was
patients with Celiac Disease, NCGS,
and possibly
autism and schizophrenia.
Quite a lot of research has been done in this area, where gluteomorphins have been found in the urine of
patients with
schizophrenia,
autism, ADHD, postpartum psychosis, epilepsy, Down's syndrome, depression,
and autoimmune diseases like rheumatoid arthritis.
But research increasingly shows that when the «white matter» that ties the gray stuff together is damaged or deficient — as it can be in
patients with brain trauma,
autism and schizophrenia — goal - directed task performance can be very poor.