Alterations in the amygdala have been reported in psychiatric disorders such as depression, anxiety disorders like PTSD,
schizophrenia and autism spectrum disorder.
Disturbances in the functioning of this network, as well as various kind of infection and other triggers of a pregnant woman's immune response, have been linked to development of psychiatric illnesses, such as
schizophrenia and autism spectrum disorders.
Not exact matches
Scientists used CRISPR - Cas9 to shed light on why people with 15q13.3 microdeletion syndrome — a rare human genetic disorder — are more likely to develop brain disorders like
autism spectrum disorder, epilepsy
and schizophrenia (Karun K. Singh, abstract 103.05, see attached summary).
The largest of its kind, the study examined genetic data in 100,000 individuals including 40,000 people with a diagnosis of
schizophrenia and also found that some of the genes identified as increasing risk for
schizophrenia have previously been associated with other neurodevelopmental disorders, including intellectual disability
and autism spectrum disorders.
Schmid says enhancing habituation
and sensory filtering in
autism spectrum disorder
and schizophrenia might have beneficial effects not only on hyper -
and hyposensitivity, but also on cognitive function.
The same conflict that gives rise to
autism and schizophrenia may be at work in all of us, nudging us one way or another on the
spectrum from father - brain to mother - brain.
They contend that mental illness can be thought of as occupying a
spectrum, with
autism at one end
and schizophrenia, bipolar disorder
and depression at the other.
In their new paper, Cheyette
and his team examined the gene DIXDC1 — a key piece of the WNT signaling pathway that is active in tissues of the brain
and interacts with DISC1, a gene implicated in
schizophrenia, depression, bipolar disorder,
and autism spectrum disorders.
Statistically significant hazard ratios for specific groups of psychiatric disorders were found for
schizophrenia and psychoses (1.27, 1.16 - 1.38), affective disorders (1.32, 1.25 - 1.39), anxiety
and other neurotic disorders (1.37, 1.32 - 1.42), mental
and behavioural syndromes including eating disorders (1.13, 1.04 - 1.24), mental retardation (1.28, 1.17 - 1.40), mental development disorders including
autism spectrum disorders (1.22, 1.16 - 1.28),
and behavioural
and emotional disorders including attention deficit hyperactivity disorder (ADHD)(1.40, 1.34 - 1.46), when compared with rates in naturally conceived children.
First, an analysis of genomic data from 6,000 patients with
autism spectrum disorders, 1,000 patients with bipolar disorder,
and 2,500 patients with
schizophrenia by co-first author Pierre - Marie Martin, PhD, a postdoctoral researcher in Cheyette's lab, revealed that disruptive mutations in the main neuronal form of DIXDC1 were present about 80 percent more often in psychiatric patients (0.9 percent had mutations) compared to healthy controls (0.5 percent had mutations).
The authors are currently applying this work to assess whether this form of attitude alignment may differ in people suffering from neuropsychiatric conditions, such as
autism spectrum disorder
and schizophrenia.
Although antipsychotic drugs are among the most widely prescribed medications, individuals with
schizophrenia, bipolar disorder
and autism -
spectrum disorders often experience severe side effects because the drugs interact with dozens of other brain receptors.
Risperidone is a commonly prescribed antipsychotic medication which is FDA approved for use for
schizophrenia, bipolar disorder,
and autism spectrum disorder.
Complementing its extensive capabilities, PsychoGenics offers a variety of validated mouse models including in - licensed transgenic models that support research in areas such as Alzheimer's disease, Huntington's disease, Parkinson's disease,
Autism spectrum disorders, psychosis /
schizophrenia, Spinal Muscular Atrophy (SMA), muscular dystrophy
and other muscle disorders.
This work has important implications for developing novel treatment strategies for psychiatric disorders associated with social cognitive deficits, including
autism spectrum disorders
and schizophrenia.
Variants of this gene have been also identified in
autism spectrum disorder
and schizophrenia.
Researchers analyzed data from three large health databases, two in Sweden
and one in Israel,
and found that a child's odds of developing an
autism spectrum disorder (ASD) tripled if he or she had a parent with
schizophrenia.
He is experienced in representing clients suffering from
autism spectrum disorder
and mental health disorders including paranoid
schizophrenia, schizoaffective disorder
and bipolar disorder.
Featuring work from world - renowned psychologists, this resource will help clinicians augment self - understanding in clients, especially those with
autism spectrum disorders,
schizophrenia,
and impaired perspective - taking abilities.