Recent research explores the effects of
a schizophrenia risk factor (DISC1) and its influence over the onset of the disease.
A Johns Hopkins University team this week reported inserting a disrupted human gene,
the schizophrenia risk factor DISC1, into lab mice, causing them to exhibit the brain asymmetry characteristic of schizophrenia as well as agitation in open spaces and trouble finding hidden food — traits reminiscent of the restlessness, impaired sense of smell and depressionlike symptoms schizophrenics suffer, Reuters reports.
Not exact matches
Back then, it was hypothesised that the A1 beta - casein protein found in the milk of some cows was a
risk factor for diabetes, heart disease and possibly also
schizophrenia and autism.
While some evidence was found to support hypotheses that cannabis use is a contributory
factor in increasing the
risk of
schizophrenia, the researchers were surprised to find stronger evidence that the opposite was also likely.
Now a large survey using data from all patients hospitalized in psychiatric wards in Israel, and their siblings, has given some answers: having a sibling with
schizophrenia increases your
risk of developing the condition by a
factor of x10, with increased
risks of developing bipolar disorder and other mental disorders.
In addition to stressful life events, trauma and family history of
schizophrenia and, the calculator takes into account five other
factors to determine an individual's level of
risk.
This suggests that the results were not wholly driven by differences in lifestyle
factors or ethnicity between the two groups, and may therefore point towards
schizophrenia's direct role in increasing
risk of diabetes.
She examined
risk factors specifically involving epilepsy, ADHD, autism and
schizophrenia.
For example, the American Psychiatric Association, which publishes the DSM, on its website describes
schizophrenia as «a chronic brain disorder,» and academic journals describe it as a «debilitating neurological disorder,» a «devastating, highly heritable brain disorder,» or a «brain disorder with predominantly genetic
risk factors.»
Hence, De Kovel and her colleagues also compared the results of their study with genetic
factors that influence the
risk of
schizophrenia.
Only half of identical twins whose siblings have
schizophrenia develop the disease, making it critical to better understand how known
risk factors such as urban environments and complications at birth contribute, he says.
The
risk of developing
schizophrenia, based on birth
factors, was compared against those who did not have
schizophrenia.
«Low birth weight and preterm birth have been proposed as
risk factors in
schizophrenia in general, but past studies have not shown a large effect on
risk,» says Dr. Bassett, who is also the Director of the Clinical Genetics Research Program at CAMH.
«We've focused our lens on these
risks in a small population with a specific genetic subtype of
schizophrenia, where the connection between birth
factors and
risk of developing
schizophrenia is noticeably stronger.»
Environmental stressors such as infection and abuse were long ago shown to be
risk factors for
schizophrenia.
«No link found between subcortical brain volumes, genetic
risk for
schizophrenia: Proof - of - concept study provides roadmap for future research into possible associations between brain volume measures, known genetic
risk factors.»
Much research has been done to identify pre-natal
risk factors for
schizophrenia.
The results of this study suggest that there are protective family environmental
factors that may reduce the
schizophrenia risk for a susceptible child by up to 86 %.
Isolating a gene that is «associated» with
schizophrenia or is a «
risk factor» for
schizophrenia doesn't necessarily have a doggone thing to do with preventing it or curing it.
I read your article very carefully, as well as all the published information available, and I am very well read in the issues of genetics and
schizophrenia, and this does not change one thing:
risk factors do not equal cause or prevention.
What we have done is identify several genetic
risk factors that greatly enhance an individual's
risk of developing
schizophrenia.
For example, emotionally turbulent families and stressful life events have been linked as
risk factors for
schizophrenia as well as for for relapses or triggers for episodes of
schizophrenia.
There is also considerable evidence indicating that stress (especially social stress and anxiety) is a
risk factor and may trigger episodes of
schizophrenia.
Dr. Malaspina continued «I think three of the interesting
factors that have been linked to the
risk of
schizophrenia are severe stress in a stress - sensitive person who has underlying genes for
schizophrenia, traumatic brain injury in those with underlying genes for
schizophrenia, and, very importantly, cannabis exposure in early adolescence.»
However, just as with many other forms of stress (complications during pregnancy and birth, drug use, head injuries, etc) that appear to be important in the
risk for
schizophrenia (especially those who have a family history of the disease), scientists suggest that child abuse may likely also turn out to be a
risk factor for some individuals.
A protein called disrupted - in -
schizophrenia 1, encoded by the DISC1 gene, has been established as a genetic
risk factor for a wide array of psychiatric disorders, including
schizophrenia, bipolar disorder, major depression,...
A multinational study of data from 130,000 people shows that inherited
risk factors for
schizophrenia and bipolar disorder also predict participation in the arts and creative professions REYKJAVIK, Iceland, 8 June 2015 — A study led by scientists at deCODE genetics...
«The fact that we were able to detect genetic
risk factors on this massive scale shows that
schizophrenia can be tackled by the same approaches that have already transformed our understanding of other diseases,» said the paper's senior author Michael O'Donovan, deputy director of the MRC Centre for Neuropsychiatric Genetics and Genomics at Cardiff University School of Medicine.
Moreover,
risk factors may be different for different individuals - while one person may develop
schizophrenia due largely to a strong family history of mental illness (e.g. a high level of genetic
risk), someone else with much less genetic vulnerability may also develop the disease due to a more significant combination of prepregnancy
factors, pregnancy stress, other prenatal
factors, social stress, family stress or environmental
factors that they experience during their childhood, teen or early adult years.
Autism is a «really complicated» disorder, and the evidence to date suggests that a combination of genes and so - called environmental
factors — some of which may increase the
risk of both autism and
schizophrenia — are involved, says Patrick F. Sullivan, M.D., lead author of the study and director of the Center for Psychiatric Genomics at the University of North Carolina School of Medicine, in Chapel Hill.
The relationship of perceived family criticism and other
risk factors to violence among patients with
schizophrenia.
A systematic meta - review grading the evidence for non-genetic
risk factors and putative antecedents of
schizophrenia
Findings suggest that genetic variants associated with traits, such as educational attainment, body mass index, and
schizophrenia, also capture environmental
risk and protective
factors.