A new Duke University study in mice links three previous and, until now, apparently unrelated hypotheses about the causes of schizophrenia, a debilitating mental disorder appearing in late adolescence that affects how people think, act and perceive reality.The brains of people with
the schizophrenia show various abnormalities, including faulty neural connections or an imbalance of certain brain chemicals.
It is not possible to poke around in people's brains to see whether those who have
schizophrenia show errors in this imprinting.
MRIs of some people with
schizophrenia show that parts of their brain are smaller than normal, a feature associated with overactive synaptic pruning in adolescence.
«People with
schizophrenia show false prediction errors: they keep thinking their predictions are wrong,» he says.
The analysis revealed that people with
schizophrenia showed markedly less brain activity during detection of the tonal changes as compared to the control group, a difference that became more apparent as symptoms worsened.
Similarly, cocaine abusers (17, 18) and alcoholics (19, 20), but not marijuana abusers (16), show attenuated DA increases in striatum when challenged with a stimulant drug, although marijuana abusers with comorbid schizophrenia or risk for
schizophrenia showed blunted DA increases to stimulants (21) and to stress (22).
Interestingly, an imaging study comparing DA increases using BPND and 4 - propyl -9-hydroxynaphthoxazine -LRB-[11C] PHNO)(radiotracer with > 20-fold higher affinity for D3 over D2 receptors, and presumably more sensitive to competition with endogenous DA)(63, 64) in response to a stressor in individuals at high risk for
schizophrenia showed that those who abused marijuana had a blunted response, consistent with decreased DA signaling (22).
Depressed patients showed an increased release of the hormone, while patients with
schizophrenia showed a decreased response.
Not exact matches
Disorganized
schizophrenia symptoms may include: Problems with thinking and expressing ideas clearly Childlike behavior
Showing little emotion Catatonic
schizophrenia symptoms may include: Lack of activity Muscles and posture may be rigid Grimaces or other odd expressions on the face Does not respond much to other people Undifferentiated
schizophrenia symptoms may include symptoms of more than one other type of
schizophrenia.
If prenatal tests
show a disposition for cystic fibrosis or
schizophrenia, should we permit abortion?
Mothers from families with pronounced mental health issues are not the sole cause of baby
showing signs of
schizophrenia, bipolar disorder, or depression.
As these new figures
show, just 6 % of all homicides are carried out by a person with
schizophrenia.
Recordings of neural activity in the frontal cortex of the rats
showed that, like humans with
schizophrenia, these rats also lacked the low frequency burst of brain activity (delta wave) during the timing task.
In recent years, he and his collaborators have in fact
shown that a reduction in KYNA improves cognition in animals that have cognitive deficits similar to those seen in
schizophrenia.
Osaka University researchers
show in a multi-institute collaboration that a single amino acid substitution in the protein CX3CR1 may act as predictor for
schizophrenia and autism
Researchers at the University of North Carolina School of Medicine have created a map that
shows how specific
schizophrenia symptoms are linked to distinct brain circuits.
However, recent laboratory studies have
shown that hedonic experience is actually intact in people with
schizophrenia, calling for new approaches to better understand these motivational deficits.
A new multi-institutional study by Japanese researchers
shows a potential rare gene mutation that could act as a predictor for two neurodevelopmental disorders,
schizophrenia and autism.
Malaspina's team was the first to
show in a 2001 paper that the most important source of these rare, sporadic changes was the paternal germline (father's sperm), with advanced paternal age explaining over a quarter of the population risk for
schizophrenia in an Israeli cohort.
Research presented at a Berlin psychiatric conference
shows teenage cannabis use hastens onset of
schizophrenia in vulnerable individuals
«Although we can not demonstrate a direct link between Candida infection and physiological brain processes, our data
show that some factor associated with Candida infection, and possibly the organism itself, plays a role in affecting the memory of women with
schizophrenia and bipolar disorder, and this is an avenue that needs to be further explored,» says Severance.
Dr Antonio Pardiñas, first author of the study, said: «We
show for the first time that genetic variants that do not severely impact gene function, but presumably have a more subtle impact on these critical genes, increase risk for developing
schizophrenia.»
Further research
showed that fetal mice bred to lack these molecules — like animals lacking MHCI, and like humans with autism or
schizophrenia — undergo inadequate synaptic pruning in some parts of their brains.
That is necessary if the organoids are to grow bigger, probably the only way they can mimic fully grown brains and
show how disorders such as autism, epilepsy, and
schizophrenia unfold.
In this study, we provide molecular evidence
showing that ZNF804A could contribute to psychiatric disorders like
schizophrenia.»
One gene, called ZNF659,
showed over-methylation in people with
schizophrenia and under - methylation in those who were bipolar, suggesting that the conditions might result from opposing gene activity (Human Molecular Genetics, DOI: 10.1093 / hmg / ddr416).
When this article was first published, the curves in the graph
showing the numbers of people not having relapses of
schizophrenia, with standard drug treatment and with minimal treatment, were reversed.
In a previous study, the researchers
showed that a group of self - described voice - hearing psychics had similar voice - hearing experiences as patients with
schizophrenia.
She says a small, unpublished study done by her group has
shown that brain training for people in the early stages of
schizophrenia reduced psychotic symptoms.
Study
shows memories formed by the same gene - silencing tool used in embryonic development; a finding could set the stage for new therapies for
schizophrenia
Professor Kieran Murphy, Head of Department of Psychiatry, RCSI and Consultant Psychiatrist at Beaumont Hospital, said: «We have
shown for the first time that dysfunction of the blood - brain barrier may be an important factor in the development of
schizophrenia.
Already this has
shown that
schizophrenia patients have particular problems noticing what has changed in a previously learned scene in which an object has been moved, but do better at recognising when the object has been replaced with something else.
People with depression and
schizophrenia are known to have a much higher risk of developing heart disease and diabetes, and elevated levels of IL - 6 have previously been
shown to increase the risk of heart disease and type 2 diabetes.
The researchers found that female mice given LPA - containing serum or LPA alone displayed hyperactivity upon stimulation,
showed anxiety and had increased numbers of dopamine - producing neurons — all which are characteristic of
schizophrenia and other psychiatric disorders.
The results of a comprehensive study conducted at the University of Haifa have
shown that Holocaust survivors are at increased risk of developing
schizophrenia.
Researchers from Orygen, the National Centre of Excellence for Youth Mental Health; the University of Melbourne; Port Phillip Prison and University Hospital of Gran Canaria Dr Negrin, Spain, have
shown that childhood sexual, physical and emotional abuse are associated with severe hallucinations in
schizophrenia and other psychotic disorders.
The study results
showed that the group directly exposed to the Holocaust had a 27 percent higher chance of developing
schizophrenia than the group indirectly exposed to the Holocaust.
«I think I can best serve the research by not being a user - advocate,» he says, heeding a healthy number of studies that
show the drug can precipitate psychiatric illnesses like
schizophrenia and cause people to engage in lethal behavior like jumping off buildings.
«This is the first time anybody has been able to separate out a genetic subtype of
schizophrenia and
show abnormal brain volume and shape correlated with it,» says Gurling.
«We
showed it could predict 90 different diseases, ranging from
schizophrenia to cancer to diabetes, with very high accuracy — without ever having talked to an expert,» Dudley says.
Various techniques for studying dominance do seem to
show that people with
schizophrenia have more right - brain activity.
Despite skepticism, research
shows how cognitive exercises benefit cancer survivors, children with attention deficits, people with
schizophrenia and others
Nevertheless, research has
shown that with proper treatment, many people with
schizophrenia can experience significant, albeit rarely complete, recovery from their illness.
Although exercise has been
shown to be an effective treatment for people with long - term
schizophrenia, no studies have assessed its effects on psychiatric symptoms in young adults with early psychosis, until now.
In a 2007 study, Sasson and his collaborators
showed 30 individuals — 10 with autism, 10 with
schizophrenia and 10 who are typical — a series of movie stills in which people express fear, anger, sadness, surprise or happiness.
To their surprise, mice lacking Arp2 / 3
showed several behaviors reminiscent of
schizophrenia.
Researchers from Hiroki Taniguchi's lab at the Max Planck Florida Institute for Neuroscience (MPFI) published a study in eNeuro in May 2017
showing for the first time that a unique type of inhibitory interneuron called chandelier cells — which are implicated in several diseases affecting the brain such as
schizophrenia and epilepsy — seem to develop their connections differently than other types of neurons.
«Low birth weight and preterm birth have been proposed as risk factors in
schizophrenia in general, but past studies have not
shown a large effect on risk,» says Dr. Bassett, who is also the Director of the Clinical Genetics Research Program at CAMH.
Low birth weight and preterm birth appear to increase the risk of
schizophrenia among individuals with a genetic condition called the 22q11.2 deletion syndrome, a new study from the Centre for Addiction and Mental Health (CAMH)
shows.
Antipsychotics were originally developed for use in patients with
schizophrenia or psychosis, but the study
shows that «off - label» prescribing of these drugs to treat the behavioural and psychological symptoms of dementia is a common practice in care homes.