Three distinct classes of drugs: dopaminergic agonists (such as D - amphetamine), serotonergic agonists (such as LSD), and glutamatergic antagonists (such as PCP) all induce psychotomimetic states in experimental animals that closely resemble
schizophrenia symptoms in humans.
Not exact matches
In Walsh's case, the disease attacked her brain, setting off a chain reaction of
symptoms that mimicked those of other mental illnesses like depression and
schizophrenia.
People with residual
schizophrenia have some
symptoms, but not as many as those who are
in a full - blown episode of
schizophrenia.
A false belief strongly held
in spite of invalidating evidence, especially as a
symptom of mental illness, as
in schizophrenia.
I also subsequently became aware that intense preoccupation with religion or spirituality and increased withdrawal / social isolation, spending significant time alone, which I would do
in order to meditate and converse with god, were
in fact
symptoms of
schizophrenia.
Alexander wrote, «Since the Orthodox world was and is inevitably and even radically changing, we have to recognize, as the first
symptom of the crisis, a deep
schizophrenia which has slowly penetrated the Orthodox mentality: life
in an unreal, nonexisting world, firmly affirmed as real and existing.
«Neurological underpinnings of
schizophrenia just as complex as the disorder itself: New analysis links cognitive, emotional, and intellectual
symptoms to neurological «disruption»
in multiple brain regions.»
Scientists have theorized that this reduction
in glutamate activity, and therefore the higher KYNA levels seen
in patients, might be connected with a range of
symptoms seen
in schizophrenia, especially cognitive problems.
Brain activation and severity of
symptoms in schizophrenia patients: Red areas represent regions related to the severity of speech fluency
in schizophrenia.
In the current study, researchers analyzed 48 ethnically diverse patients diagnosed with schizophrenia, looking at symptom sets in patients found to have rare or previously unknown changes in the DNA code of the four genes that disrupted brain functio
In the current study, researchers analyzed 48 ethnically diverse patients diagnosed with
schizophrenia, looking at
symptom sets
in patients found to have rare or previously unknown changes in the DNA code of the four genes that disrupted brain functio
in patients found to have rare or previously unknown changes
in the DNA code of the four genes that disrupted brain functio
in the DNA code of the four genes that disrupted brain function.
Classic
schizophrenia and bipolar disorder
symptoms seen
in anti-NMDA receptor encephalitis and similar conditions include hearing voices and paranoia.
It was intended to keep patients safely asleep during surgeries, but many woke up with
symptoms similar to those experienced by people with
schizophrenia, including hallucinations and the disorientation of feeling «dissociated» from their limbs, resulting
in PCP being abandoned for clinical purposes.
«A common fallacy is that
schizophrenia can be treated as a single disease,» says NYU Langone psychiatrist and lead study author Dolores Malaspina, MD. «Our biologically driven study begins to answer longstanding questions
in the field about why any two people diagnosed with
schizophrenia may have drastically different
symptoms.
«Even the timing of the emergence of
symptoms in the mice — during young adulthood — parallels the onset of
schizophrenia in humans,» said Joseph Gogos, PhD, a professor of physiology and neuroscience at CUMC, a principal investigator at the Zuckerman Institute and a lead author of the paper.
Although
schizophrenia symptoms typically appear
in late adolescence or early adulthood, genetic mutations affecting early neurodevelopment could embed risk for future behavioral changes.»
At Caltech, developmental neurobiologist Paul Patterson found he could induce the core
symptoms of autism and
schizophrenia in mice by giving their mothers the flu during pregnancy, or by arousing their immune systems
in utero with an injection of foreign RNA.
In addition to improving Parkinson's
symptoms, that same inner pharmacy can affect conditions like pain, depression, irritable bowel syndrome, anxiety,
schizophrenia and more.
She says a small, unpublished study done by her group has shown that brain training for people
in the early stages of
schizophrenia reduced psychotic
symptoms.
After his six - month trial ended, however, several patients
in the treatment group became psychotic, raising the question of whether the treatment was preventing
schizophrenia or simply controlling its
symptoms.
To test this theory, the research team designed an experiment to see if increased LPA signaling led to
schizophrenia - like
symptoms in animal models.
It may also provide clues to the winter onset of seasonal affective disorder, as well as seasonal
symptom changes noted
in psychiatric illnesses such as
schizophrenia.
For example, a participant with
schizophrenia may have mild depressive
symptoms that are not accounted for
in the treatment plan.
Mutations
in a gene that should enable memories and a sense of direction instead can result
in imprecise communication between neurons that contributes to
symptoms of
schizophrenia, scientists report.
Led by Brenda Penninx, PhD, of the VU University Medical Center
in Amsterdam, the Netherlands, the study found that patients with an early age at onset and higher
symptom severity have an increased genetic risk for MDD, bipolar disorder and
schizophrenia.
Lately, the drug has also been
in the news as a possible treatment for
schizophrenia, after psychotic
symptoms disappeared
in a young Japanese man treated with the antibiotic for pneumonia.
People with
schizophrenia are usually diagnosed
in their teens or 20s, but may experience
symptoms for years beforehand, such as minor delusions or paranoid thoughts.
A Johns Hopkins University team this week reported inserting a disrupted human gene, the
schizophrenia risk factor DISC1, into lab mice, causing them to exhibit the brain asymmetry characteristic of
schizophrenia as well as agitation
in open spaces and trouble finding hidden food — traits reminiscent of the restlessness, impaired sense of smell and depressionlike
symptoms schizophrenics suffer, Reuters reports.
Fish oil supplements have been investigated as a treatment for adults with
schizophrenia, but so far results have been mixed — four trials found no benefit while another four found a small reduction
in symptoms.
Such atypical antipsychotic medications as Clozaril (clozapine), Risperdal (risperidone) and Zyprexa (olanzapine), most of which were introduced
in the 1990s, appear to ameliorate
schizophrenia symptoms by affecting the function of neurotransmitters such as dopamine and serotonin, which relay chemical messages between neurons.
Although exercise has been shown to be an effective treatment for people with long - term
schizophrenia, no studies have assessed its effects on psychiatric
symptoms in young adults with early psychosis, until now.
Mounting evidence indicates that disturbances
in the brain's glutamate pathway contribute to
symptoms of
schizophrenia.
For example, blocking this receptor
in patients suffering from an incoherent sense of self such as
schizophrenia could improve their
symptoms as well as their social abilities.
In this study, the researchers compared the severity of negative symptoms and proline levels in 95 hospitalized schizophrenia patients with variants of the COMT gen
In this study, the researchers compared the severity of negative
symptoms and proline levels
in 95 hospitalized schizophrenia patients with variants of the COMT gen
in 95 hospitalized
schizophrenia patients with variants of the COMT gene.
Antipsychotics were originally developed for use
in patients with
schizophrenia or psychosis, but the study shows that «off - label» prescribing of these drugs to treat the behavioural and psychological
symptoms of dementia is a common practice
in care homes.
Among those patients who were being treated with valproate (approximately one - third of the
schizophrenia patients), negative
symptoms were more severe
in those with the Met / Met gene than
in those with the Val / Val gene.
Two new phase III clinical trials investigating the efficacy and safety of bitopertin, a glycine uptake inhibitor considered to be a promising new add - on therapy for treating negative
symptoms in schizophrenia, failed to show a benefit of the drug over placebo.
The team measured levels of anandamide
in the cerebrospinal fluid (CSF) of 47 people suffering their first bout of
schizophrenia, but who had not yet taken any drugs for it, and 26 people who had
symptoms of psychosis and have a high risk of
schizophrenia.
In the Brezhnev era a new disease was described: «sluggish» or «creeping»
schizophrenia, the only
symptom of which was the expression of politically unacceptable views.
A sample of mental health professionals — counselors, social workers, psychologists, case managers and others — living
in Washington read vignettes portraying people who had
symptoms of depression or
schizophrenia.
New research has identified the mechanisms that trigger disruption
in the brain's communication channels linked to
symptoms in psychiatric disorders including
schizophrenia.
No single genetic mutation can ever account for the complex range of
symptoms that arise
in devastating neuropsychiatric disorders such as
schizophrenia.
The molecules produced during gluten digestion include exorphins, which have also been found
in the spinal fluid of people with
schizophrenia and autism, and are thought to worsen the
symptoms of these neurological diseases.
The team wondered if other retroviruses might cause these
symptoms in separate diseases such as
schizophrenia.
However, there is increasing evidence that computer - assisted training and rehabilitation can help people with
schizophrenia overcome some of their
symptoms, with better outcomes
in daily functioning and their lives.
«The cortical folding pattern itself may not be so important, but the disturbances
in connections between brain regions implicated by the changes
in cortical folding could provide critical clues to deficits
in the integrity of brain circuits that contribute to
symptoms and functional impairment
in schizophrenia,» commented Dr. John Krystal, Editor of Biological Psychiatry.
Similar to what is found
in adults with
schizophrenia, for the subgroup of subjects with pre-illness scores, there was an initial steep decline
in IQ, from about 2 years prior to 1.7 years after onset of psychotic
symptoms.
Childhood onset
schizophrenia (COS) is rare, but occurs
in children who show
symptoms of
schizophrenia prior to the age of 13.
These authors argue that this pattern of a plateau
in IQ despite persisting psychotic
symptoms and substantial gray matter loss argues against a neurodegenerative model of
schizophrenia for COS especially since they found improvements on certain subtests of IQ.
In this diffusion tensor imaging (DTI) study, the authors investigated white matter integrity in schizophrenia and the relationships between white matter alterations and specific symptoms of t
In this diffusion tensor imaging (DTI) study, the authors investigated white matter integrity
in schizophrenia and the relationships between white matter alterations and specific symptoms of t
in schizophrenia and the relationships between white matter alterations and specific
symptoms of the
«This new study ties
in well with previous research into the mental processes that give rise to some of the
symptoms of
schizophrenia such as paranoia and believing
in things that aren't based
in reality.