Sentences with phrase «scientists modeled disease»

When the scientists modeled disease transmission, they found that while an «infected person's 11 nearest neighbors faced a greater than 80 percent chance of infection,» Wired reports, «all the remaining passengers, however, had a lower than 3 percent risk.»

Not exact matches

Medicines that are personally tailored to your DNA are becoming a reality, thanks to the work of U.S. and Chinese scientists who developed statistical models to predict which drug is best for a specific individual with a specific disease.

Scientists for the first time have assembled a «disease in a dish» model that pinpoints how a defect in the blood - brain barrier can produce an incurable psychomotor disorder, Allan - Herndon - Dudley syndrome.

Scientists study VSV, which causes acute disease in livestock but typically does not lead to illness in people, as a model for viruses that are harmful to humans.

For the research, the scientists used the platform to target colon macrophages in order to reduce inflammatory symptoms caused by Inflammatory Bowel Disease (IBD) in mouse models.

The scientists then tested three new mTOR inhibitors currently under development (pp242, AZD8055 and INK128) in combination with the chemotherapies AraC, Etoposide and Cisplatin to see how they affected laboratory lines of leukemia cells and mouse models of the disease.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

Instead of systematically testing the effects of known compounds — the pharmaceutical industry's basic model for more than a century — scientists can now investigate backward, combing through genomic data to find links between specific genotypes and diseases and then screening drug data to identify therapeutic candidates.

«Scientists are excited because this technology allows us to make animal models that we weren't able to see before — for brain diseases, Alzheimer's, schizophrenia,» she says.

So until recently, much of what scientists learned was gleaned by inference or from studying mouse models of the disease.

Now, a team of scientists at the Icahn School of Medicine at Mount Sinai have developed the Just EGFP Death - Inducing T - cell, or JEDI T - cells, which enable the visualization of T - cell antigens, allowing researchers to study T - cell interactions with different cell types, model disease states, and finally determine the functions of otherwise poorly characterized cell populations.

Using experimental models and state - of - the - art technology, the scientists found that switching off this protein leads to better control of glucose production from the liver, revealing a potential new target that may be used to treat type 2 diabetes and other metabolic diseases.

Using a pig model may help other scientists more effectively test treatments for colon cancer, type 2 diabetes and other chronic diseases.

Mouse embryonic stem cells, reported in 1981 by Martin Evans, Matthew Kaufman, and Gail Martin, have allowed scientists to generate genetically customized strains of mice that have revolutionized studies of organismic development and immunity and have provided countless models of human disease.

In a mouse model of Alzheimer's pathology, the scientists observed that trained microglia amplified the formation of plaques even months after their immunological memory had been triggered, thus causing the disease to become more severe.

Although it's still unknown exactly why DHA is able to prevent the onset of lupus, the researchers said this study provides scientists with a better model for looking at just how much DHA is needed to ward off the environmental trigger of the disease.

But Majumder, a scientist who specializes in mathematical modeling, saw something different in the splotches of light pink: a disaster for infectious disease surveillance.

In the current study, published in Nature Communications, the scientists created a new animal model of disease to determine if BBB leakage can cause autoimmunity.

Scientists have developed the first true animal model of Huntington's disease, a progressive and often fatal deterioration of the central nervous system.

«Our hope is that by creating this system, we can continue our own investigations into other harmful organisms, and that other scientists worldwide can adapt our zebrafish model to investigate the diseases that are priorities in their communities,» Perfect said.

Using genetic engineering technology, a team of scientists has established a pig model of Huntington's disease (HD), an inherited neurodegenerative disease.

But how effective are these preclinical models in actually mimicking the disease and giving scientists the ability to develop real comparisons?

In a development that could lead to a new generation of drugs to precisely treat a range of diseases, scientists from the Florida campus of The Scripps Research Institute (TSRI) have for the first time designed a drug candidate that decreases the growth of tumor cells in animal models in one of the hardest to treat cancers — triple negative breast cancer.

The condition is not only untreatable, but seems to be peculiar to humans, meaning scientists have been unable to study the disease and seek new treatments by modeling it in an animal like the mouse.

In humans, α - synuclein would not necessarily turn out to be equally aggressive — mouse models of neurodegenerative diseases do not mimic human disease very closely — but scientists are taking the possibility seriously.

Scientists use it as a model organism for studying cellular signals, disease, and the movement of cells in response to a chemical stimulus (chemotaxis).

Scientists also tested the drug in a mouse model of muscular dystrophy, since prednisone is normally given for this disease.

Aside from a regenerative therapy to replace ailing organs, the scientists add that the NPCs could be used to model diseases in the lab.

To narrow down the number of chemical compounds that could be potential drug candidates, scientists utilize computer models that can predict how a particular chemical compound might interact with a biological target of interest — for example, a key protein that might be involved with a disease process.

A zebrafish model of Dravet syndrome, a severe form of pediatric epilepsy, may help scientists quickly find drugs for the devastating disease.

Now scientists regularly use iPSCs to model diseases using cells that would be otherwise difficult to obtain from a living person or animal.

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have successfully tested a potent synthetic compound that prevents type 1 diabetes in animal models of the disease.

We see this as a model for how scientists should unite to combat infectious diseases of all kinds.»

Scientists working with a mouse model of Parkinson's disease have found that caffeine prevents the loss of the neurotransmitter dopamine, which is depleted in the neurodegenerative illness.

Clevers and other scientists have developed organoids of the gut, liver, lung, brain, and many other human organs that can be used to model disease or to serve as test beds for drugs.

The animal model which was used to examine the long - term effects of metabolic syndrome * enabled the scientists to elucidate new mechanisms that cause fatty liver disease and also show how it can develop into liver cancer.

Scientists at the Gladstone Institutes discovered that changing a specific part of the huntingtin protein prevented the loss of critical brain cells and protected against behavioral symptoms in a mouse model of the disease.

Scientists in the lab of Steve Finkbeiner, MD, PhD, discovered that modifying the huntingtin protein prevented cell death and motor impairment in a mouse model of Huntington's disease.

«What we've shown in the monkey model matches a lot of what people have observed in epidemiological studies of humans,» says Emma Mohr, a pediatric infectious disease fellow at UW — Madison and first author on the study with Matthew Aliota and Dawn Dudley, research scientists in UW — Madison's schools of Veterinary Medicine and Medicine and Public Health, respectively.

It is also intended for post-docs and scientists already working in certain of these fields and who are interested in expanding their knowledge on the potential applications of these new techniques to their models or in neighbouring pathophysiological models of analysis of genes or diseases using genetically modified animals.

Scientists often talk about animal «models» of Huntington's disease.

The scientists suggest that the models could be key to better understanding the condition and its complex relationship to certain diseases.

A group of scientists have described their use of a specific gene therapy to treat Alzheimer's disease in a mouse model.

No doubt, knowledge of the mouse genome will help scientists design more effective mouse models for human disease and disorder.

But now, scientists at the Gladstone Institutes have found a way to efficiently edit the human genome one letter at a time — not only boosting researchers» ability to model human disease, but also paving the way for therapies that cure disease — by fixing these so - called «bugs» in a patient's genetic code.

Researchers have developed an array of mouse models to help scientists understand a whole collection of human diseases.

A team of Chinese and American researchers led by Dr. Ji - jing Pang of the Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, PR China, and including Jackson Laboratory scientist Bo Chang, M.D., used gene therapy to restore cone function in the retinas of the B6 (A)- Rpe65rd12 / J (005379) mouse, a model of Leber congenital amaurosis — even if the disease has progressed for three months (Li et al. 2011; Pang et al. 2005).

WashU biomedical scientist G.S.M Sundaram, PhD., holds a model of the molecule fluselenamyl, which may improve PET scans for patients with Alzheimer's disease.

Now, after years of painstaking research, scientists have succeeded in duplicating the disease's most critical features in the most readily manipulated model organism in existence.

Another behavior that scientists have observed in Huntington's disease model mice is that they aren't as motivated as normal mice to drink sweet water.