Sentences with word «scopolamine»

These assays have previously been used to probe deficits with scopolamine treatment [94 — 97].

The acetylcholinesterase inhibitor, donepezil, which transiently improves cognition in AD, reverses the cognitive impairment induced by scopolamine in both humans and animals [92, 93].

Mice were given J147 alone, donepezil alone and J147 + donepezil in food before the cognitive behavioral assays, including the Y - maze, a two - day water maze and fear conditioning were done in the presence of scopolamine treatment.

Mice were injected with 1 mg / kg of scopolamine or saline 30 minutes prior to testing.

(B) Treatment with scopolamine significantly increased the time taken to find the platform compared to saline controls in the two day water maze.

While that sounds innocent enough, Datura stramonium, as it is known in the scientific world, belongs to the deadly nightshade family and contains high levels of anti-cholinergic alkaloids such as scopolamine, hyoscyamine and atropine.

All mice received scopolamine except for one of the control groups, which received saline as a control.

-RSB- In Romania, researchers noted similar activity using inhaled lavender for an hour each day and, according to the study, «Taken together, our results suggest that antioxidant and antiapoptotic activities of the lavender essential oils are the major mechanisms for their potent neuroprotective effects against scopolamine - induced oxidative stress in the rat brain,» that can lead to severe illness and cancer.

Prescription preventions like Scopolamine patches work well, too.

Bülow's group is beginning to see similar results in Datura, a plant that makes the anti-motion-sickness drug scopolamine.

In some cases animals are trained on tasks and then made amnesic either by electric shock, or, in one popular test, by administering scopolamine to deplete acetylcholine.

To examine alterations in brain activation associated with pharmacologically induced memory impairment, we used functional MRI (fMRI) to study the effects of lorazepam and scopolamine on a face - name

Results from the treatment groups revealed that all three groups, J147, donepezil and J147 + donepezil, rescued the decrease in spontaneous alternations induced by scopolamine demonstrating an improvement in short - term working memory (Figure 4A).

However, J147 and donepezil together had a synergistic effect with the combination significantly increasing the freezing response compared to scopolamine control.

Memory impairment was induced with scopolamine at 1 mg / kg 30 minutes before behavior testing in all groups except one of the control groups, which received saline as a control.

The ability of compounds to reverse scopolamine - induced cognitive impairment is used as a model for demonstrating drug target engagement and cognitive enhancement in both humans and animals [91].

However, the combination of J147 + donepezil significantly improved memory compared to scopolamine suggesting a synergistic effect of the two compounds in this assay of hippocampal - dependent associative memory (Figure 4C).

The study gave subjects ten days of aGPC or placebo before inducing temporary amnesia with a potent drug called scopolamine [2].

Scopolamine significantly decreased the freezing response.

During the recovery, the victim is forced to consume datura, a plant that contains chemicals such as scopolamine and hyoscyamine, powerful hallucinogens that leave the individual delirious and compliant.

Meanwhile, Maura Furey of the National Institute of Mental Health and her colleagues are following up on the discovery that intravenous delivery of scopolamine, a motion - sickness drug, relieves depressive symptoms in people within days.

All three assays demonstrated cognitive deficits with scopolamine treatment compared to saline controls (Figure 4A - D).

[13] In Romania, researchers noted similar activity using inhaled lavender for an hour each day and, according to the study, «Taken together, our results suggest that antioxidant and antiapoptotic activities of the lavender essential oils are the major mechanisms for their potent neuroprotective effects against scopolamine - induced oxidative stress in the rat brain,» that can lead to severe illness and cancer.

Motion sickness tablets or Scopolamine patches (Scopoderm) can be purchased from your local chemist.

J147 and J147 + donepezil rescued the deficit in spatial navigational memory caused by scopolamine in the water maze but donepezil alone failed to rescue the deficit (Figure 4B).

However, the combination of J147 and donepezil significantly reversed the memory deficit caused by scopolamine treatment (Figure 4D).

From 1914 to the late 1960 «s, the new fad in pain relief in childbirth was «twilight sleep», or scopolamine & morphine, whereby a woman was rendered completely immobile and / or semi-conscious in labour and childbirth.

There were also dangerous side - effects to scopolamine (mainly hemorrhaging and transference of medication to the newborn), hence it became an unpopular method of pain relief and its phasing out made way for the most common and effective pain relief in labour and childbirth that is still used today — the epidural.

By the 1930s it was common practice and women were always anesthetized with a mix of morphine and scopolamine.

«I've tried lots of things: scopolamine, benzodiazepines, antipsychotics,» Dawson says.

During the 1970s, research with animals also suggested that acetylcholine might be a key neurotransmitter in memory formation; for instance drugs such as scopolamine, which deplete brain acetylcholine also impair memory.

A novel extended sequence learning task (ESLeT) for rodents: validation and the effects ofamphetamine, scopolamine and striatal lesions

The researchers tested the drug on several dozen rats treated with scopolamine, a chemical that interferes with a neurotransmitter critical to learning and memory.

Typically, a rat treated with scopolamine will never learn the location of a submerged platform in a water tank, orienting with cues outside the tank.

The scopolamine - treated mice took a considerable amount of time to find the hidden platform compared to saline controls (Figure 4B).

The comparison between J147 and donepezil in the scopolamine model showed that while both compounds were comparable at rescuing short term memory, J147 was superior at rescuing spatial memory and a combination of the two worked best for contextual and cued memory.

The scopolamine - treated mice spent significantly less time freezing than saline controls in response to the context indicating they did not remember the environmental context (Figure 4C).

Three different behavioral assays, Y - maze, two - day water maze and fear conditioning, which have previously been used to assay deficits with scopolamine treatment [94 — 97] compared the ability of compounds to reverse cognitive impairment induced by scopolamine.

Following two weeks of treatment, memory impairment was induced by intraperitoneal (i.p.) injection of scopolamine (1 mg / kg) 30 minutes prior to each of the following behavioral tests: Y - maze, probe trial of the water maze and contextual and cued fear conditioning.

For the scopolamine experiment, normal mice were given an i.p. injection of saline or 1 mg / kg scopolamine 30 minutes before the first hidden platform trial on Day 2.

While J147 and donepezil alone did increase the freezing response compared to scopolamine, it was not significant.

The available data suggest that reversal of scopolamine - induced cognitive impairment is a viable model for predicting pharmacodynamic signals of cognition enhancing compounds in animals [91].

Therefore, the effect of J147 on the cholinergic system was investigated using the muscarinic receptor antagonist, scopolamine, which decreases central cholinergic neuronal activity.

We compared J147 to donepezil in the scopolamine - induced memory impairment model using the same cognitive behavioral assays that were used for reversal of memory impairment in old AD mice.

J147 and donepezil in a scopolamine induced model of memory impairment.

Scopolamine significantly decreased the freezing response and while J147 did increase the freezing response compared to scopolamine it was not significant.

Both J147 and the combination of J147 + donepezil rescued this deficit in spatial memory created by scopolamine to a similar extent, but donepezil alone failed to rescue the deficit (Figure 4B).

Donepezil did not improve memory with the mice showing freezing times similar to scopolamine (Figure 4C).