Sentences with phrase «screen small molecule inhibitors»

Our team is currently developing methods that can be used to screen small molecule inhibitors of EDD1 and also looking into how the regulation of TIP60 levels can be translated into therapeutic advances for the treatment of viral - mediated cancers such as cervical cancer.

Not exact matches

In this study, the researchers screened a library of 200,000 small molecule compounds to identify potential inhibitors of Ebola virus RNA synthesis.

Application of high - throughput screening to identify a novel αIIb - specific small - molecule inhibitor of αIIbβ3 - mediated platelet interaction with fibrinogen.

Identification of small molecule inhibitors of Cisplatin - induced hair cell death: results of a 10,000 compound screen in the zebrafish lateral line.

Identification of novel small - molecule inhibitors of glioblastoma cell growth and invasion by high - throughput screening.

She remained in Sheffield to complete a PhD and short post-doc in the lab of Professor Beining Chen, primarily working to screen and characterise small molecule inhibitors of anthrax toxins as part of a collaboration with the Health Protection Agency at Porton Down.

Our group has 3 major goals: Develop novel therapeutic approaches based on centrosomal clustering To further develop our first prototype inhibitors of centrosomal clustering preclinically and to establish a robust and specific high throughput small molecule screen Discover key events in myeloma pathogenesis To investigate the pivotal transition from the pre-malignant, asymptomatic to malignant, symptomatic stages of plasma cell dyscrasias in order to understand the pathophysiology and thereby identify novel targets Translate small molecule therapeutics from bench to clinical trials To evaluate novel agents in the preclinical setting and to initiate early phase clinical trials in hematologic malignancies with focus on multiple myeloma

He went on to a postdoctoral position with Dr. Iwao Ojima evaluating anti-tubercular compound series that inhibit the cell division protein FtsZ and screening computationally designed small molecule inhibitors of Botulinum neurotoxin.

More recently, the team published the structure of Eis in complex with two potent inhibitors they'd discovered using high - throughput screening of approximately 123,000 small molecules.

21) Somwar R, Erdjument - Broonage H, Larsson E, Shum D, Lockwood WW, Yang G, Sander C, Ouerfelli O, Tempst PJ, Djaballah H, Varmus H (2011) SOD1 is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines.