To find out what impact this might have on a flu epidemic, Earn and his colleagues turned to a 1982 study which showed that ferrets, a common animal model for human flu, produced
more seasonal flu virus if their fevers were lowered either with painkillers or by having their fur shaved off.
In contrast, when
the seasonal flu virus becomes drug resistant, its ability to move among hosts and grow within them is reduced.
The findings, several years in the making, could lead to a better understanding of how
the seasonal flu virus, which typically originates in birds, makes its way to humans.
Fouchier later added, however, that his mutant virus «does not spread yet like a pandemic or
seasonal flu virus» and that the ferrets did not die when infected through aerosol transmission.
Meanwhile, in the southern hemisphere, in the midst of its winter flu season, swine H1N1 virus seems to be replacing
the seasonal flu viruses that circulated till now — classic pandemic behaviour.