Vaccination programmes begin in the US and Europe, but many healthcare workers are reluctant to have the vaccine, even though it is virtually identical to
the seasonal vaccines used in previous years, which have a good safety record.
Not exact matches
Novavax says that during Phase IIa of
seasonal flu
vaccine testing, which began in May, it was able in the majority of people tested to surpass the FDA's requirements for producing enough antibodies to protect the body from the H3N2, H1N1 and B viruses — all of which were common enough a year ago to be
used to develop flu
vaccines for the 2008 to 2009 flu season.
Although the world's attention is focused on the novel H1N1 virus causing the swine flu pandemic, H3N2, a
seasonal strain of influenza, has popped up in many East Asian countries — and some variants in circulation may outfox the
seasonal vaccine in
use.
Kieny said that for reasons that aren't fully understood,
vaccine companies that
use eggs to grow
vaccine viruses get yields of only 25 % to 50 % of those obtained during the production of
seasonal vaccine.
While this year's
vaccine is a much better match to the circulating
seasonal strains of influenza, the shifty nature of the virus and the need to pick the viruses
used to make global
vaccine stocks well before the onset of the flu season can make
vaccine strain selection a shot in the dark.
During the 2014 - 15 flu season, the poor match between the virus
used to make the world's
vaccine stocks and the circulating
seasonal virus yielded a
vaccine that was less than 20 percent effective.
A trivalent inactivated
seasonal influenza
vaccine (TIV)
used in humans will be compared directly in mice, ferrets and pigs.
«The study by Egli et al. holds promise for enhancing the response of the
seasonal influenza
vaccine by blocking the receptor
used for the innate immunity signalling molecule IL28B.
Using mathematical modelling, the authors discuss the potential population - level benefits that a universal
vaccine would offer over conventional
seasonal vaccines.