Sentences with phrase «second line therapy»

Laparoscopic ovarian diathermy (LOD) is an alternative second line therapy for women with PCOS that is resistant to the number # 1 ovulation induction drug.

Phase II / III Biomarker - Driven Master Protocol for Second Line Therapy of Squamous Cell Lung Cancer

Not exact matches

Then colchicine, which has unusual anti-inflammatory properties, proved effective as a treatment for gout, and eventually became a second - line therapy for pericarditis.

Second, Darzalex secured an important FDA label expansion last year for its use as a second - line multiple myeloma treatment rather than only as a third - line thSecond, Darzalex secured an important FDA label expansion last year for its use as a second - line multiple myeloma treatment rather than only as a third - line thsecond - line multiple myeloma treatment rather than only as a third - line therapy.

you could have a point there My dear old dad was having radio therapy last summer and the guy who drove him to his appointments has a 15 year old son in the youth team who quiet freely stated that in the dressing room the rumour is that Theo has lost his bottle and does nt want to injured again.Thing is he was in my opinion NEVER really that good he is great if he has no time to think about his last touch but give him that extra second and he fluffs his lines continuously He is also really really lazy and he really looks like he just cant be bothered and AW giving him a contract extension AND wage increase just shows how far from reality the changing room has become.

Commenting on the trial, Dr Alice Shaw, director of thoracic oncology at the Massachusetts General Hospital Cancer Centre in Boston, US, said: «This is the first randomised study to examine how a second generation ALK inhibitor compares to standard second line chemotherapy in ALK positive patients who failed the standard first line therapy, which currently is crizotinib.»

It represents a real advance in the second - line treatment of advanced bladder cancer because pembrolizumab is the first therapy to show a significant survival advantage over chemotherapy for these patients.

Therefore, it may benefit patients both as a first - line and second - or later - line treatment, by producing a durable clinical benefit and with a reduced toxicity profile compared to current EGFR inhibitor therapies.

If these fail, doctors are forced into a trial - and - error approach with second - and third - line therapies, hoping to get lucky.

«Most patients who receive a second - line therapy have a life expectancy of about six or seven months, so to have four patients still ongoing at two years is very encouraging,» Alley said.

The standard first - line therapy treatment involves chemotherapy, and currently there is no approved second - line therapy.

The poor survival in advanced ovarian cancer is due both to late diagnosis, as well as to the lack of effective second - line therapy for patients who relapse.

The Food and Drug Administration (FDA) approved nivolumab as second - line therapy for these patients this past July, and clinical trials are underway to test the drug as frontline treatment.

The primary endpoint was response and time to PSA progression after second - line therapy.

Phase II study of cediranib (AZD 2171), an inhibitor of the vascular endothelial growth factor receptor, for second - line therapy of small cell lung cancer (NCI # 7097).

There are no highly effective second - line therapies.»

As a single agent, ipilimumab is approved as a second - line treatment, as well as adjuvant therapy for patients with completely resected melanoma.

The trial is one of several that the company is conducting on nivolumab for lung cancer, both as first - and second - line therapy and in combination with other drugs.

«The more robust response rates of first - line therapy, compared with second or later lines, suggest that immunotherapy administered earlier in the disease course is more beneficial,» says Dr. Adams.

The really important questions are whether this therapy can be given safely; early in the disease course; and as second - line treatment, replacing an autologous stem cell transplant.

For example, cognitive behavioral therapy (CBT) had small positive effects on disability and catastrophic thinking.66 Exercise therapy reduced pain and improved function in chronic low back pain54; improved function and reduced pain in osteoarthritis of the knee51 and hip52; and improved well - being, fibromyalgia symptoms, and physical function in fibromyalgia.48 Multimodal and multidisciplinary therapies helped reduce pain and improve function more effectively than single modalities.55, 67 Multiple guidelines recommended acetaminophen as first - line pharmacotherapy for osteoarthritis68 - 73 or for low back pain74 and nonsteroidal anti-inflammatory drugs (NSAIDs) as first - line treatment for osteoarthritis or low back pain70, 74; first - and second - line drugs for neuropathic pain include anticonvulsants (gabapentin or pregabalin), tricyclic antidepressants, and serotonin - norepinephrine reuptake inhibitors (SNRIs).75 - 78 Nonsteroidal anti-inflammatory drugs have been associated with hepatic, gastrointestinal, renal, and cardiovascular risks.63, 73,79

Zonisamide — this is a sulfa - class medication that is used as a second or third - line treatment, however, it can also be used as a first - line therapy.