The contribution of adversity
variables over the life - course in mediating excess risks of common mental disorders and poorer self - rated health at midlife was assessed.31 To assess mediation, three criteria needed to be fulfilled.31 First, the association of parental migration history with putative
mediator was assessed using multivariable logistic regression.31
Second, the association of the putative
mediator with the outcome
variable (poorer self - rated health and common mental disorders at midlife) was assessed using multivariable logistic regression.31 Finally, the association of parental migration history with outcome --(either midlife common mental disorders or poorer self - rated health at midlife) was assessed in the presence of the putative
mediator.31 If the coefficient for the association between parental migration history and outcome was reduced in the presence of the putative
mediator, then it was presumed that the data were consistent with mediation.31