In higher than normal concentrations, certain bile acids and their breakdown products (metabolites) are toxic to your pet (eg
the secondary bile acids made by bacteria in the intestine from liver bile acids, lithocholic and deoxycholic acids appear the most toxic).
The proportion of
secondary bile acid was lower in dogs with EPI (70 % [6 — 96 %]-RRB- compared to healthy control dogs (93 % [12 — 97 %]; P = 0.0431).
In a study by Birkett and coworkers (1997), it was necessary to achieve a stool weight of 150 g to improve fecal markers for colon cancer, including fecal bulk, primary to
secondary bile acid ratios, fecal pH, ammonia, and transit time.
High doses of resistant starch (28 - 60 grams / day) have shown improved regularity (increased fecal bulking with softer stools), and reduced
secondary bile acids, ammonia and phenolics.
Bile acids need to be converted into
secondary bile acids in the body to function as they should, and probiotic gut bacteria are how it's done.
Those eating vegetarian produce just a fraction of some of
the secondary bile acids implicated in cancer, about 70 % less.
These bacteria are primarily responsible for activating
the secondary bile acids in your colon.
Put people on a plant - based diet and within just one week, the bacterial enzyme activity to produce
these secondary bile acids is cut in half.
This may help explain the extraordinarily low rates of colon cancer in sub-Saharan Africa, with native Africans putting out just a fraction of
the secondary bile acids compared to African - Americans.
Certain bacteria in the colon transform bile acids into
secondary bile acids.
Walnut Consumption Alters the Gastrointestinal Microbiota, Microbially Derived
Secondary Bile Acids, and Health Markers in Healthy Adults: A Randomized Controlled Trial
Commensal bacteria likewise aid in nutrient extraction and assimilation, as
the secondary bile acids and short - chain fatty acids they produce from fermentation of indigestible carbohydrates lead to liberation of compounds like peptide YY from cells, which decreases intestinal transit, encourages satiety, maximizes nutrient absorption, and increases energy harvested from food (Boulange et al., 2016).
Structural and functional characterization of BaiA, an enzyme involved in
secondary bile acid synthesis in human gut microbe.
Biologically active gut microbe - derived metabolites, such as short chain fatty acids,
secondary bile acids, polysaccharide A, 4 - ethylphenylsulfate, indoxyl - sulfate, p - cresyl - sulfate, and trimethylamine - N - oxide, are now recognized as contributors to type 2 diabetes and related kidney disease and cardiovascular disease (CVD).
Reduction in hepatic
secondary bile acids caused by short - term antibiotic - induced dysbiosis decreases mouse serum glucose and triglyceride levels — Takuya Kuno — Scientific Reports
The data generated from this group revealed that the reduced hepatic inflammation by antibiotics was accompanied by decreased free and conjugated
secondary bile acids in a gender - dependent manner.
The work of Schoonjans» team suggests that this process can be coordinated by
secondary bile acids, metabolites that are generated by our liver and gut bacteria.
Not exact matches
These were
secondary tumours from 71 people with cancers that had spread from the bowel, oesophagus or
bile duct.
Extended cases of cholestatic liver disease in dogs can cause
secondary copper buildup — an effect of irregular
bile passage.
«With severe liver disease, a
secondary condition occurs where there is retention of
bile,» Goldstein says.