Sentences with phrase «secondary lymphoid»

The lymphoma can vary in aggression, although often will quickly go on to affect the primary and secondary lymphoid tissues.

Secondary lymphoid organs, which include the lymph nodes, tonsils and spleen, act as traps for incoming pathogens, whereupon foreign bodies are set upon by mature lymphocytes.

The secondary lymphoid organs include lymph nodes, spleen, appendix, tonsils, adenoids and Peyer's patches (lymphoid tissue present in the small and large intestines).

Perhaps the greatest attraction and chief benefit of intratumoral therapies is their ability to synergize with systemic checkpoint therapies and accelerate the development of a lymphoid infiltrate and perhaps secondary lymphoid structures in vivo, which in turn can result in systemic mobilization of a T - cell response: the local injection — global effect model.

Basophils amplify the synthesis of autoantibodies by accumulating in secondary lymphoid organs.

[31] Recent studies show that the vaginal mucosa can support T - cell induction in the absence of MALT or secondary lymphoid tissues, suggesting that the type II vaginal mucosa can itself act as an inductive site for the generation of primary CD8 + T - cell immune responses.

Masters et al. discuss the often overlooked contribution of the stromal microenvironment as an extrinsic factor to immunosenescence and inflammation.12 Accumulation of senescent stromal cells which demonstrate the senescent associated secretory phenotype (SAPS), may alter tissue structure and function, and increase local inflammation.13 The impact of altered lymphoid stromal microenvironment may be widespread and include altered haematopoiesis, reduced lymphatic flow and disrupted secondary lymphoid organisation, which consequently will alter antigen transportation and presentation to T cells.12

The phenotype of NP cells generated ex vivo (Figure S8) closely resembles that of central memory CD4 + T cells found in vivo, which persist for years in secondary lymphoid organs and can differentiate into effector memory CD4 + T cells [45].

Lymph nodes are considered secondary lymphoid organs, a group that includes tonsils, spleen and adenoids.

Thus, natural antibodies play a crucial role by preventing pathogen dissemination to vital organs and by improving immunogenicity through enhanced antigen - trapping in secondary lymphoid organs.