[3,4] Despite these advances, the late toxicities of chemotherapy and increased risk of
secondary malignancies with RT have threatened the survival rates and quality of life of Hodgkin lymphoma patients.
«But a complementary way to give it in a targeted way — such as going directly to the tumor and giving a lot of it — can decrease the systemic toxicity and hopefully prevent
secondary malignancies.»
A possible combination therapy to lessen the risk of paradoxical activation and the emergence of
secondary malignancies is combining BRAF inhibitors with other inhibitors.
However, a type of cellular signaling caused by the BRAF inhibitors may leave patients susceptible to
secondary malignancies, such as squamous cell carcinoma and RAS - mutant leukemia.
Not exact matches
An estimated 18 percent of
malignancies in the United States are
secondary cancers that develop in cancer survivors.
Although, Hedrick and Linden target different cell types, innovations by both groups could encourage clinical tests of drugs designed to switch on a patient's immune cells by eradicating
secondary lung
malignancies.