Sentences with phrase «secondary mutations»

Currently, many patients who acquire resistance to EGFR - targeted therapy undergo a tumor biopsy and are designated as either positive or negative for specific secondary mutations.

We show that H274Y decreases the amount of neuraminidase that reaches the cell surface and that this defect can be counteracted by secondary mutations that also restore viral fitness.

Researchers examined tumor samples for various genetic causes of EGFR resistance, including T790M, the most common secondary mutation.

Although these two mutant alleles are both homozygous - viable, we used them in transheterozygous combination (i.e., CCHa2 - RKO51 - 2 / CCHa2 - RTAL - 34) to avoid the effects of any unexpected secondary mutations.

Along the same lines, in non-small cell lung cancer (NSCLC), acquired resistance to Gefitinib / Erlotinib kinase inhibitors has also been associated with a secondary mutation of the gatekeeper Thr790 residue of the epidermal growth factor receptor (EGFR).