The authors transplanted human cortical ‐ derived neural progenitor cells engineered to
secrete glial cell line ‐ derived neurotrophic factor (GDNF) into the cortex of a rat model of ALS, where the cells migrated, matured into astrocytes, and released GDNF.
Functional efficacy was further enhanced when hNPC were genetically engineered to
secrete glial cell line - derived neurotrophic factor.
Not exact matches
Some recent studies have suggested that
glial cells can
secrete chemical messengers such as glutamate and ATP; if so, these «gliotransmitters» could influence neuron activity.
Astrocytes, one type of
glial cells are the supporting
cells for survival and function of neurons in the brain by
secreting many kinds of neuroprotective molecules.
Whether GBPs are the only
secreted factors capable of performing this function, and whether they are also able to regulate ILP secretion in other
cells like the
glial cells, remains to be discovered.
In this study, we will examine whether
glial cells and certain proteins
secreted from these
cells influence axon regeneration and guidance in the optic nerve in adult mice.