Sentences with word «secretome»

A Novel Role for CAMKK1 in the Regulation of the Mesenchymal Stem Cell Secretome.

The study underscores the utility of a quantitative secretome profiling strategy in identifying novel bacterial virulence factors.

In a study in Molecular & Cellular Proteomics, Xiaoyun Liu and colleagues at Peking University applied quantitative secretome profiling to catalogue the effector proteins delivered by SPI - 1.

Quiescent PSCs in a normal pancreas act as lipid - storing cells with a limited secretome, whereas activated PSCs in the tumor microenvironment produce a vast array of secreted proteins implicated in cancer progression.

These findings support a role for STAT5 in regulating the ABL1 / ABL2 - dependent secretome.

The successful candidate will receive extensive training on proteomics - based discovery (secretome proteomics to identify cytokines important in different children's cancers, protein expression profiling of subcellular fractions and organelles, and interactome proteomics to identify novel protein — protein interactions) and follow - up of proteomic findings (molecular cell biological characterization of protein functions and signaling).

«The mammary epithelial cell secretome and its regulation by signal transduction pathways.»

Importantly, the pro-regenerative effects of CM from modified MSCs suggest that CAMKK1 acts by modulating the secretome of MSCs to produce elevated levels of pro-reparative factors.

Therefore, PMA is a general tool for studying the secretome and has the added specific benefit of enabling examination of secreted proteins involved in HMEC function.

Results: Researchers at Pacific Northwest National Laboratory have identified the secretome — defined as the family of proteins secreted by cells — of human mammary epithelial cells, or HMEC.

Review of «A Novel Role for CAMKK1 in the Regulation of the Mesenchymal Stem Cell Secretome» from STEM CELLS Translational Medicine by Stuart P. Atkinson

Narrowing the potential secretome with these comparisons, the team's analysis yielded a conservative estimate of 151 proteins belonging directly to the secretome.

Why it matters: Because the secretome is important for tissue function and equilibrium as well as cell communication, proliferation and organization, studying these proteins may lead to new treatments and biomarker discovery.

Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome.

RNAseq and mass spectrometry to identify the astrocyte - specific transcriptome and secretome, across development both in vitro and in vivo

For all cell lines, we observed a gradient of expression of the two antigens in the cell population (Figure 1a), as we reported previously, and confirmed in an independent analysis of the secretome of human ES cells [16].

Dr. Gerlinde Van de Walle, an Assistant Professor in the department of Microbiology and Immunology, will be giving a seminar titled Bovine mammary stem cells and their secretome: why do we care?