Other genes influence brain development in even stranger ways (
see Brain Genes (above).
Not exact matches
On the contrary, he finds it useful to ponder an array of reductionist attempts to explain the existence of religion, from that which seeks to pinpoint the area of the human
brain or the specific
genes connected to religiosity to that which
sees religion as a malfunction of the human mind or a vestigial remnant from a primitive stage of human development suitable only for whimpering, immature dullards (a point of view championed by the new atheists).
The study found mutations in 607
genes in
brain tissue from patients who died from SUDEP that were not
seen in the tissue from the living people.
For example, mice have been given an extra color vision
gene in the lab, and it has been shown that the protein manufactured by that
gene expands the scope of their vision by enhancing their ability to
see longer - wavelength light without any other changes in the
brain.
The center is now planning a study to look at
genes involved in sensitization in the
brain, to
see if they are activated in chemically sensitive individuals.
«I was expecting to find that a few
genes would be evolving rapidly, while probably the overall distribution would be changing at about the same rate among all the primates, but instead we
saw that the
brain's
gene evolution in the human lineage has actually slowed down,» Wu says.
To test this hypothesis, an international team led by evolutionary biologist Philipp Khaitovich of the Shanghai Institutes for Biological Sciences in China and the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, set out to
see how many
brain - related
genes implicated in schizophrenia underwent positive natural selection since humans and chimpanzees diverged from a common ancestor between 5 million and 7 million years ago.
In future experiments, Lahn will insert the human ASPM
gene into mice to
see what affect it has on
brain development.
The significance of the new model, according to Grange, is that «it enables us to now have a biological understanding of the patterns, the co-expression profiles,
seen in the Allen
Gene Expression Atlas of the Mouse
Brain.»
«Additional studies are needed to
see if these nanoparticles could also effectively deliver other antitumor
genes for the treatment of
brain tumors as well as systemic cancers.»
2015 will
see the start of the first human clinical trial of a
gene silencing or huntingtin - lowering drug, which specifically aims to reduce production of mutant huntingtin in the
brains of HD patients.
In these images of rat
brains, differences in
gene expression of
genes for fibroblast growth factor 2 (FGF2, top set) and dopamine 2 receptor (D2, bottom sett) can be
seen in rats of two breeds before (left) and after (right) cocaine exposure.
Gregory Foltz of Swedish Medical Center in Seattle
saw that BEX1 was turned off in the
brains of his tumor patients, and using the
Brain Atlas, he confirmed that the
gene is usually active in healthy
brains, as reported in Cancer Research in 2006.
«One could imagine, say, if you introduced
genes involved with
brain growth during development, that you might actually
see a bigger
brain or a differently structured
brain,» he explains.
The next step, he says, is to investigate how embryonic mouse
brains with induced folds develop as they mature past the fetal stages of development and to look across species to
see if the
gene has similar effects in other mammals.
To
see what
genes might be involved in this increased aggression, the team used microarrays to look for differences in
gene expression in fly
brains.
Last year, University of Chicago geneticist Bruce Lahn reported that he had uncovered
genes that are still evolving in humans, and he suggested that they confer a
brain - related boost (
see main text).
The same effect was
seen in a mouse model of human
brain cancer containing this
gene fusion.
Walsh and colleagues found that knocking out this
gene disturbs the centriole's organization and function, suggesting an underlying biochemical mechanism for the
brain deficits
seen in the ferrets.
«It was exciting to
see that half of the domestication signals in the genome point to
genes that have to do with
brain development and function», says professor Kerstin Lindblad - Toh, senior author and director of SciLifeLab Uppsala, and scientific director of vertebrate genome biology at the Broad Institute.
To
see how the two
gene versions affect the living human
brain, the NIMH researchers scanned 24 healthy young adults twice using PET (positron emission tomography), which uses radioactive tracers to visualize
brain function.
These include metabolic
genes that provide the fuel for a
brain,
seeing as nervous tissue requires a lot more energy than other cells.»
We can
see and measure resilience in terms of how kids»
brains, immune systems, and
genes all respond to stressful experiences.
Also
see Claudia Liebl et al,
Gene expression profiling following maternal deprivation: involvement of the
brain renin - angiotensin system, Frontiers in Molecular Neuroscience., May 2009, Volume 2, Article 1