Not exact matches
The significance of the new model, according to Grange, is that «it enables us to now have a biological understanding of the patterns, the co-
expression profiles,
seen in the Allen
Gene Expression Atlas of the Mouse Brain.»
Rather than measuring genetic changes directly (such as single nucleotide polymorphisms, otherwise known as SNPs), McKee and her group typically do RNA
expression profiles on patients to
see what
genes are being expressed.
In vitro experiments and high - throughput RNA sequencing revealed that CTCF deletion profoundly altered the B lymphocyte transcriptional program, shifting cells from a
gene expression profile typical of the germinal center to one more similar to that
seen in plasma cells.
We took a second muscle biopsy to
see what happened to their individual
gene expression profile, which is a genetic portrait of
gene activity.
Given that changes in
gene expression profiles will likely be
seen after a short period exposure to drugs, and that most cells had undergone cell death in as little as 8 hours (Fig. 3E — G), we compared
gene expression of cells prior to and after 4 hours of exposure to the drugs.
Also
see Claudia Liebl et al,
Gene expression profiling following maternal deprivation: involvement of the brain renin - angiotensin system, Frontiers in Molecular Neuroscience., May 2009, Volume 2, Article 1