Sentences with phrase «seen at higher doses»

Although a complete fertility evaluation of characteristics such as sperm morphology was not performed, the complete absence of sperm seen at higher doses indicates likely contraceptive effect.

We're seeing them at higher doses than the chemicals beekeepers apply directly to the colonies to control varroa mites.

Vandenberg and Catanese report that «although these same effects were not seen at the higher dose, more than 10 percent of females exposed to 2 microgram BPS / kg / day either killed their pups or provided such poor instrumental maternal care that one or more pups needed to be euthanized.

Not exact matches

«And at the higher dose, we saw a rescue of the neural stem cell pool in aged mice.»

Colvin says she already sees strong evidence of hyperalgesia in high - dose opioid users at the clinic where she works.

But at higher — albeit still modest — doses, it produced repetitive behaviors similar to the tooth - grinding and compulsive skin - picking seen in human meth and MDPV users.

Lloyd - Jones's editorial is based on a large new study published in the journal that looked at adults, ages 50 to 80, with cardiovascular disease who took extended - release niacin (vitamin B3) and laropiprant (a drug that reduces face flushing caused by high doses of niacin) to see if it reduced heart attack and stroke compared to a placebo over four years.

While biased agonists may be able to be used more safely at higher doses than other opioids, it remains to be seen how other side effect profiles will be affected.

«We did see that giving a higher dose of the drug seemed to produce a better methylation response among patients,» says Valerie Lee, M.D., a fellow at the Johns Hopkins Kimmel Cancer Center.

Knockdown of approximately 75 % was seen at day 7 at a dose of 0.1 mg per kilogram and 90 % at day 14 at a dose of 0.3 mg per kilogram, with more than 70 % suppression persisting at day 28 in the high - dose group.

On the basis of the current studies as well as previous reports on the use of intradermal immunization against influenza, hepatitis B, rabies, and other infectious diseases, 2,3,8 it is becoming clear that use of the intradermal route may at least partially overcome the relatively poor influenza - specific immune responses seen in certain at - risk populations, particularly the elderly, in whom the immune response in general is known to diminish with age.9 Moreover, in times of shortage, the dose - sparing intradermal approach might be particularly well suited to the young, healthy persons included in the CDC's high - priority group for vaccination, such as health care workers, as well as to younger, otherwise healthy populations in general.

First, the effects of the first dose of PRX002 on serum AS in PD patients were similar to what was seen in young, healthy people in the first trial: up to a 97 % decline in the ratio of free to total AS at the highest dose, with the ratio remaining strongly suppressed for at least four hours (Figure 4, left).

With all that in mind, researchers at the University of Minnesota School of Public Health wanted to see if there's been an increase in people taking high doses of these supplements.

«You can start seeing adverse effects with chronic use at high doses,» says Stephen Stone, MD, a professor of dermatology at the Southern Illinois University School of Medicine in Springfield, Illinois.

For instance, one study on mature broccoli noted genotoxic effects at high doses, but the same results were not seen with broccoli sprouts.

Clinically, I have seen time and again that if you give humans the nutrients they need at high doses they feel and perform better.

The ingredients do have studies backing their effectiveness, but they are added in at a very low dose and the user may only see results when taking a higher dosage.

I think docs prescribe that amount of doxy for Lyme diseases, but I've also seen a study praising doxy's effects when taken at higher doses.

Individuals with high levels of insulin see better improvements in insulin sensitivity than healthy individuals at the same dose of resistant starch.

From fig. 2, we can see that iodine supplementation in groups II and III actually increased the CD4 + to CD8 + ratio, until the onset of autoimmune symptoms at very high doses in Group IV when the ratio decreased.

If no improvement is seen after 1 month at the higher dose or if at any time clinical signs progress, the dog should be re-evaluated.

Penicillins are generally safe, but at excessively high doses, neurotoxicity or elevation in liver enzymes could be seen.

For dogs, neurologic signs may be seen at doses 400 mg / kg and higher; ferrets, however, are particularly prone to developing neurologic signs and may do so at much lower doses than dogs.

When metronidazole is used at moderate to high doses over a long period, you could see neurologic symptoms, including ataxia (wobbliness), difficulty walking, or abnormal eye movements.

Most ivermectin based heartworm preventives do not carry a high enough dose of ivermectin to kill whipworms, though at other doses ivermectin could be used (with appropriate cautions - see link).

«We know what doses the animals were given, and when we look at humans, we see blood levels within that range or actually higher, which is a cause of concern and should stimulate more human research,» said Jerrold Heindel of the National Institute of Environmental Health Sciences.

«But as I commented at scienceprogress, the way I see the ledger, the religious Right gets a handful of anti-science points for views on evolution (and related rationalizations about the age of the earth, etc.), and for some dismissal of climate change theory, but the Left gets many more anti-science points for exaggerating the health and ecological risks of POPs; DDT; GMOs; plastics and plasticizers; pesticide residues; conventional agriculture; low - dose EM radiation; high - tension powerlines; climate change; population growth; resource depletion; chemical sweeteners; species extinction rates; biodiversity decline; and I'm sure the list could go on.