Sentences with phrase «seen in any clinical trial»

This is one of the biggest reductions in death I've seen in any clinical trial for adult cancers.

The lab tested more common hydrogels but found that they were unable to provide the same controlled release and also failed to provide an additional benefit over CDN treatment seen in clinical trials.

Thus far, such side effects seen in clinical trials have been minor, but it sometimes takes years of exposure to a drug before deadly infections show up, he says.

Similar patterns of reduced T3 and elevated cortisol excretion were recently seen in a clinical trial of a 10 % carb weight maintainance diet.

This set of propositions allowed us to use control conditions in a within - subject multiple baseline design similar to those seen in clinical trial research [65].

Not exact matches

«Watson is able to give us faster, better matching of patients to potential clinical trials that our oncologists wouldn't have otherwise be able to see — and I sit with our oncologists who work on this kind of thing,» Christopher Ross, CIO at the Mayo Clinic, told MobiHealthNews in an interview.

In addition, I think we're going to see — or begin to see — a radical rethinking of the clinical trials process.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

«We continue to experience encouraging signs of clinical benefit in our trial addressing NHL, but we also recognize the unfortunate and unexpected toxicity we saw in our trial addressing ALL with JCAR015,» Bishop stated.

And a clinical trial to see whether cord blood transplants improve symptoms of children with autism spectrum disorder should wrap up in the summer of 2018, says pediatric researcher and clinician Joanne Kurtzberg of Duke University, who helped establish a not - for - profit umbilical cord bank in North Carolina.

He didn't see how he could survive, but he decided to enroll in the clinical trial of Keytruda anyway.

«There are currently no therapies which successfully reverse the damage seen in the more than 12,000 individuals who suffer a spinal cord injury each year in the United States alone,» says Dr. Richard G. Fessler, professor of neurological surgery at Rush University Medical Center and principal investigator for the Phase 1 clinical trial involving AST - OPC1 (oligodendrocyte progenitor cells).

«This is a fairly niche effort in lung cancer care, and we'd like to see a national level clinical trial at some point,» he said.

«If we find that lymphoscintigrams using tilmanocept are at least as good as the conventional radiocolloid tracer in identification and visualization of sentinel nodes, we would like to see a randomised clinical trial involving large numbers of patients,» says Prof de Bree.

It's probably clinical trials in large populations, such as testing to see if a reduced - salt diet reduces blood pressure.

«That would be a great result if it was seen in a normal clinical trial of a drug.»

Gentzsch noted potential reasons to explain why patients in the clinical trial saw benefit from the two drugs even though her team's lab experiments produced evidence to the contrary.

«After just three treatment cycles, we saw tumor markers plummet and some patients» tumors shrink significantly in just nine weeks,» said Gayle Jameson, nurse practitioner and principal investigator of the clinical trial, who is highly encouraged by the response.

Vtesse is currently running a late - stage clinical trial of the drug, a large sugar molecule known as a cyclodextrin, in which it is injected by lumbar puncture into the spinal fluid of children with the disease (see «Why are people fighting over a promising treatment for a fatal childhood disease»).

«If you take a snapshot of a clinical trial at any given point in time, you can see almost anything,» he says.

The study can be seen in Cell Reports and provides an explanation for why the clinical trials for Alzheimer's disease drugs have failed and gives new light on the discord between preclinical and clinical findings.

2015 will see the start of the first human clinical trial of a gene silencing or huntingtin - lowering drug, which specifically aims to reduce production of mutant huntingtin in the brains of HD patients.

But sometime within the next few years, Min and Rhee plan to run clinical trials in humans to see whether FlaB - enhanced bacteria could work as a safe, effective anticancer therapy.

Conventional drug discovery remains a hit - and - miss affair and Hunter believes the 50 percent failure rates seen for experimental compounds in mid - and late - stage clinical trials due to lack of efficacy is unsustainable, forcing a shift to AI.

I've run certain clinical trials but mostly at this point partner with some of my clinical colleagues to test the hypotheses generated in the lab in the clinic, in actual patients, and then actually try to analyze tumors from those patients to see whether the patterns that we identified in the laboratory in fact hold true in patients.

«I can see neurofilament becoming a valuable tool to assess neuroprotection in clinical trials so that we can more quickly figure out whether new drugs are doing what we need them to.

Punjabi and others look forward to formal clinical trials, in which researchers can start testing methods of intervention and treatment to see if they can bring the risk of mortality in check.

The third millennium will see pharmaceutical - driven clinical drug trials in India as a «sunrise industry.»

In clinical trials, MannKind's treatment has not given rise to the weight gain often seen with other insulin therapies, perhaps because diabetics do not need to snack between meals to avoid hypoglycemia, Richardson says.

At relapse, he was seen by physicians at Dana - Farber Cancer Institute and was enrolled in a clinical trial for the Notch inhibitor BMS - 906024.

«Our next step is to see how long we can extend the cycling pattern, and test some of the STAT3 inhibitors currently in clinical trials for other indications such as cancer, as this could accelerate testing in humans,» added Sacco.

An early stage clinical trial in humans, run by firm NoNO in Ontario has also seen positive results.

«In recent years we've seen a significant improvement in the length of good - quality life men can hope to live even with the most advanced prostate cancers — thanks to clinical trials giving us several new prostate cancer drugIn recent years we've seen a significant improvement in the length of good - quality life men can hope to live even with the most advanced prostate cancers — thanks to clinical trials giving us several new prostate cancer drugin the length of good - quality life men can hope to live even with the most advanced prostate cancers — thanks to clinical trials giving us several new prostate cancer drugs.

Porter points out that tPA was not included in the clinical trial because a good result was seen with ultrasound / microbubbles alone in the pig study.

While the last decade has seen many potential new agents for hepatocellular carcinoma fail in clinical trials, phase I and II data from early regorafenib trials were promising, and led to the initiation of this international, multi-center phase III trial.

They will test the best candidate molecules in mice to see if they can replicate their study findings, before moving on to human clinical trials.

Clinical trials of weight loss have been shown to improve participants» mood, but this could be a result of the supportive environment rather than the weight loss itself, as the effects are seen very early on in treatment and are not related to the extent of weight loss.

In 1999, researchers based at 27 centers across the U.S. launched a clinical trial to see whether individuals prone to type 2 diabetes could reduce their chances of developing the disease by adopting a healthy lifestyle.

Conn said the next steps will be clinical trials to see whether the same technique can work in humans.

In clinical trials, the pioneering diagnostic — developed by researchers at University College London (UCL) and the Western Eye Hospital — allowed doctors to see individual nerve cell death in the back of the eyIn clinical trials, the pioneering diagnostic — developed by researchers at University College London (UCL) and the Western Eye Hospital — allowed doctors to see individual nerve cell death in the back of the eyin the back of the eye.

With miglustat therapy available off - label in the U.S. and potential therapies in clinical trials, the researchers said their goal is to see the test added to the recommended uniform screening panel defined by the U.S. Department of Health and Human Services (HHS).

In the first clinical trial of the drug, called G3139, 43 per cent of the 14 patients saw a measurable shrinkage in their tumours after treatment, says Burkhard Jansen of Vienna UniversitIn the first clinical trial of the drug, called G3139, 43 per cent of the 14 patients saw a measurable shrinkage in their tumours after treatment, says Burkhard Jansen of Vienna Universitin their tumours after treatment, says Burkhard Jansen of Vienna University.

screening - the process clinicians use to see if a volunteer is eligible to participate in a clinical trial.

The Patient Advisory Group of the International Coordinating Committee (ICC) for SMA Clinical Trials has published a family - friendly set of guidelines for care in spinal muscular atrophy (SMA)-- click here to download the guide — to complement the physician guidelines published in August (for more on the physicians» consensus statement, see The Journal of -LSB-...]

«We are very pleased to see the great milestone of a disease - modifying drug treatment advancing into clinical trials in SMA patients,» said Kenneth Hobby, President of Families of SMA.

Cagan's lab recently received approval from the US Food and Drug Administration to begin a clinical trial in colorectal and medullary thyroid carcinoma to see if fly avatars can successfully help guide patient care.

Only then would clinical trials begin to see if a drug that works in a rat will work in a human.

Heidi's unrelenting style can be seen across all areas of Hookipa, including a major role in the clinical strategy, scientific advice and clinical trial application for the Vaxwave cytomegalovirus vaccine candidate HB - 101.

«This is an exciting development, but the new vaccines now need to be tested in clinical trials to see how well they work in humans.

Spark Therapeutics» gene therapy for patients with haemophilia has seen some early success in clinical trials, after being tested in 10 male patients