Sentences with phrase «seen in mouse models of the disease»
«The compounds identified in this study, when administered orally, both reduced the inflammation that is a hallmark of multiple sclerosis and protected against the nerve cell damage seen in mouse models of the disease,» said Jeffery Haines, PhD, a post-doctoral fellow at Mount Sinai and the study's lead author.
https://www.sciencedaily.com/ Not exact matches
«It would be interesting to model some of these diseases in mice and see if supplementing NMN provides any benefit to their behavior or memory.»
The scientists then tested three new mTOR inhibitors currently under development (pp242, AZD8055 and INK128) in combination with the chemotherapies AraC, Etoposide and Cisplatin to see how they affected laboratory lines of leukemia cells and mouse models of the disease.
Taking this one step further, the researchers performed the same experiments in a mouse model of Alzheimer's disease to see if these astrocytic adenosine receptors were also involved in memory loss associated with the disease.
Although genetically modified mice have been used widely to model neurodegenerative diseases, they lack the typical neurodegeneration or overt neuronal loss seen in human brains, says corresponding author Xiao - Jiang Li, MD, PhD, distinguished professor of human genetics at Emory University School of Medicine.
To see whether blocking CD47 could reverse plaque buildup, the group tested the experimental anticancer antibody drug in several different mouse models of cardiovascular disease.