Not exact matches
Whether investigating fat
cells, immunotherapy or use
of the CRISPR - Cas 9 gene - editing tool, which a federal panel recently approved for a
select number of patients suffering from three types
of cancers, including multiple myeloma, approaches beyond attacking cancer
cells are needed in the fight against many cancers.
Gerton hypothesized that cancer
cells, which are highly proliferative and might need more than the usual amount
of ribosomes, would
select for expansion
of copy
number.
Reasoning that the
selected T
cells, to be effective, would have to make up the bulk
of cells in each patient's immune system, the team administered chemotherapy to the patients to temporarily wipe out substantial
numbers of existing immune
cells.
This BaF3 phe116 almost completely fails to proliferate and activate STATs in response to IL - 9.15 However, upon prolonged culture with IL - 9, a small
number of cells manage to survive and even proliferate, allowing an IL -9-dependent
cell line (BaF3 phe116 / 9) to be
selected.14 In contrast to parental BaF3 phe116
cells, those IL -9-
selected cells could progress to autonomous
cells (BaF3 Aut) after a second selection step in the absence
of cytokine.
«When we
selected an application, we knew we needed a tiny
number of cells and they just needed to do what they were doing in the petri dish,» Lanza says.
Each circle in the histogram represents a single randomly
selected field (total
number of cells counted > 500 for each group).
Prior research had developed a
number of new compounds making use
of a novel drug discovery paradigm which begins with natural products extracted from plants; it then entails
selecting synthetic derivatives which demonstrate efficacy in multiple assays testing protection against different factors
of the nerve
cell damage and death which take place in brain injuries and in age - associated neurodegenerative conditions.
(Quick tip: instead
of selecting individual
cells,
select the entire column or row by clicking on the letter or
number associated with it.