Sentences with phrase «selected genes»

They work by binding to receptors inside a cell, which then travel to the nucleus and act on the DNA by turning select genes on and off.

Cells can be transfected with selected genes with specific properties as a means of evaluating the mechanisms of interaction between cells and chemicals.

A scan for positively selected genes in the genomes of humans and chimpanzees Nielsen, R., C. Bustamante, A. G. Clark, S. Glanowski et al. 2005.

A multiple sequence alignment of selected genes from all 95 unique, fully - sequenced adenovirus genomes in GenBank and TMAdV is performed and the results displayed as a radial phylogenetic tree.

A scan for positively selected genes in the genomes of humans and chimpanzees.

Kaur et al. [68] examined selected gene expression patterns in rat retinas from 3 to 14 days after hypoxia.

With the manipulation of DNA by selecting our gene makeup (genotype), can we select for our desired phenotype?

The probability of a randomly selected mutation in a randomly selected gene having precisely that effect is quite low, so just as with the stones in the field, a positive finding is more likely than not to be spurious — unless the experiment is unbelievably successful at sorting the wheat from the chaff.

«Those modern humans» selected genes under selection may prove central to a relevant process of domestication, given that these interactions may provide significant data on relevant phenotypic traits,» said Boeckx.

Thanks to this transmission route, human and animal cells respond to external signals and specifically activate selected genes in the cell nucleus.

So in a real sense, estrogen and progesterone receptors are constantly reprogramming our cells by turning selected genes on and off.

These data establish the recent origin of P. falciparum and further provide an explanation for the abundant diversity observed in antigen and other selected genes.

They observed that selected genes including some oncogenes and tumor suppressor genes are similarly altered in these two types of cancers.

This work shows that evolution can rapidly select the gene variants needed to adapt to more acid conditions, says Jennifer Sunday, an ecologist at Simon Fraser University in Burnaby, Canada.

How do genetic mutations in selected genes lead to elective degeneration in certain types of neurons in HD, PD, and ALS?

A new study suggests that DNA methylation analysis of select gene promoters can identify the optimal pluripotent stem cell for bone repair strategies

LDA analysis for RNA transcription of selected genes located throughout the B. burgdorferi cN40 genome in flaB DNA - positive heart base (HB) and tibiotarsal (Tt) tissue samples from infected mice at 12 months following treatment with saline or antibiotic.

In contrast with the changes in cell signaling, muscle mRNA responses of selected genes associated with muscle proteolysis and catabolism were largely unchanged between treatments.

«This large study is particularly notable for having used 31 publicly available genomes plus select genes from about 90 additional isolates,» said corresponding author Cheryl Kuske of the Bioenergy & Biome Sciences group at Los Alamos National Laboratory.

Statistically significant differences among control, hypoxic and recovery values were determined for (a) select gene expression values, as measured by qRT — PCR and (b) among time points for HIF - 1α mRNA and protein expression.

For example, we discovered how the protein phosphatase calcineurin and its downstream effector protein NFAT act synergistically with the transcription factor MEF2 at transcriptional enhancer elements of selected genes, such as myoglobin, to medicate adaptive mechanisms by which skeletal myofibers acquire specialized contractile and metabolic properties in response to changing patterns of muscle contraction.

«Filter» hones GWAS results to help researchers avoid dead ends: A new strategy gives scientists a biologically informed way to select genes to study.»

Selecting a gene to study from these extensive lists had been highly speculative.

A closer look revealed epigenetic changes, such as methylation and histone modification, which shut down selected genes, often in response to environmental stresses.

Much more research is needed on how gene drive would work under different environmental conditions or whether the selected genes would spread to other species or change in some way over time.

To get around this obstacle, he uses precision breeding: Instead of mixing entire sets of the DNA from two parents, he selects the gene needed for a specific trait such as resistance to a disease and inserts it into a recipient grape.

Recent innovations have made it easier than ever to «knock out» or silence the expression of selected genes.

By suppressing genes that are active in the developing embryo, silenced just before birth, and re-activated years later in many advanced cancers, the let - 7 family of «microRNAs» — tiny snippets of RNA that can put the brakes on expression of selected genes — appears to prevent human cancer cells from reasserting their prenatal capacity to divide rapidly, travel and spread.

Many of the selected genes will be used to study disease processes and underlying mechanisms.

An adapted CRISPR technique could be used to treat incurable diseases, such as diabetes and muscular dystrophy, by turning up the volume on selected genes.

Given the tailored inhibition of selected genes and the added precision brought by targeted delivery systems, RNAi - based therapies are thought to carry lower risk of failure than traditional approaches as the biological effects are more predictable.

In the second study, researchers led by Dr. Pellizzoni demonstrate that SMN deficiency disrupts mRNA splicing in vivo, resulting in detrimental effects on select genes that contain a rare type of intron.

To explore these further, we selected the genes showing a fold change of four or higher and searched for enriched functional terms.

In addition to the visualization of expression profiles during ES cell differentiation, the search engine provides links to analyze the selected genes using many publicly available tools and resources.

«The task at hand is to select the genes that are most critical to AML cells, but are not needed by normal cells.

The capacity to genetically engineer mouse models of cancer by either knocking - out or knocking - in selected genes of interest affords the opportunity to follow in - vivo tumor progression (and regression) and metastases.