Sentences with word «selectin»

The King Lab has pioneered the use of selectin proteins to deliver apoptosis death signals to tumor cells in flowing blood, and to deliver therapeutic cargo (e.g., siRNA, chemotherapeutics) encapsulated in nanoscale liposomes.

Here, ultrasensitive mass spectrometric analyses revealed that the sialyl - Lewisx sequence [NeuAcα2 - 3Galβ1 - 4 (Fucα1 - 3) GlcNAc], a well - known selectin ligand, is the most abundant terminal sequence on the N - and O - glycans of human ZP.

First, the P - Selectin proteins on the platelet membrane bind to the CD44 proteins on the surface of the cancer cell, locking it into place.

By blocking selectin function, some of the inflammatory signaling can be lessened.

The vote on delegate selectin would be held in November of 2018.

The team will also be looking to identify which molecule L - selectin binds to in virus infected tissues that allows killer T cells to be directed there.

Further studies will be required before the findings can be translated into direct benefit to patients; however, the team are planning on focusing their efforts at finding ways to reduce the loss of L - selectin from the surface of killer T cells in order to increase the number of killer T cells that can home in on infected tissues.

In case of chronic, unwanted inflammation, this blocking of selectin - related signals can provide important health benefits.

Once the cell reaches its destination — the site of inflammation — the calmodulin protein enters the equation to shed the L - selectin protein, allowing it to enter the inflamed tissue.

Low levels of oxygen and nitric oxide both increase expression of P - selectin.

The study also points to a potentially new therapeutic target, the self - adhesion molecule P - selectin, which the researchers found played a central role in increased red blood cell adhesion.

Fertilization in humans is initiated by binding of spermatozoa to a selectin ligand on the egg's extracellular matrix.

Published Thursday January 21st, 2016 in the journal Cell Reports, a team from Cardiff University's Systems Immunity Research Institute identify a molecule in the body — known as L - selectin — which directs the body's killer T cells to the site of a virus.

Generation of a Th2 microenvironment through interleukin - 13 (IL - 13) stimulation induced features of asthmatic airways and induced vascular wall activation through increased expression of E - and P - Selectin, but did not alter rhinovirus growth.

The selectin adhesion receptors important in leukocyte, stem cell, and CTC trafficking have unique biophysics that make them ideal for targeted drug delivery.

Two proteins, L - selectin and calmodulin, are involved in the process.

«Cell biologists had figured out in 1998 that calmodulin was negatively regulating the shedding process of L - selectin,» says Jessica Gifford, a PhD student supervised by Hans Vogel.

Using powerful magnets and a technique called nuclear magnetic resonance (NMR) spectroscopy, Gifford and Vogel determined the molecular structure of the interaction between the two proteins, providing important insight at the molecular level into how calmodulin controls the shedding of L - selectin.

The first, L - selectin, is found within the membrane itself of the white blood cell.

During inflammatory responses by the body, selectins are important in allowing inflammatory signals to be transmitted through the cell.

Some of these benefits appear to take place through the blocking of selectins and from inhibition of an enzyme called phospholipase A2.

Selectins are sugar - protein molecules (glycoproteins) that run through cell membranes.

This is where you're going to find the selectin of models you want for the drive and the auto financing that will make it affordable for you to have the drive you want on the roads around Markham, IL.

Flowcytometric detection of the expression of P - selectin and platelet derived membrane microparticles as markers of platelet activation in cats with aortic thromboembolic disease and hypertrophic cardiomyopathy.

Flowcytometric detection of the expression of P - selectin, platelet bound antibody (IgG), and the presence of platelet derived microparticles as markers of platelet activation in dogs with immune - mediated hemolytic anemia.

Comparing the expression of P - selectin and platelet derived membrane microparticles as markers of platelet activation in cats with aortic thromboembolic disease and hypertrophic cardiomyopathy pre - and post-clopidogrel therapy.