Epitope mapping of
a selection of antibodies using peptide arrays containing 175 000 peptides covering hundreds of proteins.
This catalog offers a detailed choice of the most commonly used cell markers and an extensive
selection of antibodies used in immunology.
The facility staff advises on protocols and
selection of antibodies and assists in tissue processing, image acquisition and image processing.
For the new study, the team set out to do a proof - of - principle
selection of antibodies that can bring about a different effect: protecting cells against an otherwise certain death.
Not exact matches
In part, because
of the absence
of immune
selection, which plays a role in the introduction
of drift, so there are not many
antibodies.
This information leads us to believe that these sites are under «
selection pressure» by the therapeutic, meaning that the
antibody cocktail binds and promotes elimination
of the original virus, while the escape variants continue the infection.»
The generation
of the germinal centers requires B cells to undergo a complex transcriptional program to allow them to divide rapidly, modify their
antibody genes, and pass through a
selection procedure that induces either their survival or their death.
But this
selection method has one drawback: it determines an
antibody's ability to activate a desired biological pathway in a cell by measuring the resulting proliferation
of that cell — a slow and only narrowly applicable indicator.
«The time from
selection of the target through discovery
of the
antibody and completion
of initial animal tests totaled only about five months,» said Hongkai Zhang, a research associate in the Lerner laboratory who was first author
of the study.
The malarial genes under the most intense
selection pressure — those with the most variation, generated over a millennium - long cat - and - mouse game with the immune system's
antibody response — are the ones that encode the identifying proteins on the surface
of the parasite.
«For the first time, we have a
selection method whose power matches the vast diversity
of the
antibody repertoire,» said Richard A. Lerner, the Lita Annenberg Hazen Professor
of Immunochemistry at TSRI, member
of the Department
of Molecular Biology, and senior investigator for the new study, which appears in this week's issue
of the Cell Press journal Chemistry and Biology.
Lerner, Zhang and their colleagues are currently using the new
selection method to find other useful
antibodies for a variety
of applications.
Take advantage
of the best and most dependable
selection of blocking / neutralizing
antibodies on the market.
Obtained as a Fab by
selection against gp120 IIIB
of an
antibody phage display library prepared from bone marrow
of a asymptomatic HIV - 1 seropositive donor.
Our proprietary
antibody discovery technology quickly characterizes every cell in complex immune systems, powering our
selection of drug targets, identification
of drug candidates and preclinical assessment
of efficacy.
Through long - established collaborations in Durban and Kimberley, these studies in particular seek to define: the immune responses that are effective in control
of HIV infection; the impact
of HLA - mediated
selection pressure on HIV at the individual and population level; the mechanisms
of HIV non-pathogenicity; the nature and consequences
of ontogeny
of the virus - specific immune response; and finally the prospects for interventions including antiretroviral therapy, alone or in combination with broadly neutralising
antibodies and / or T - cell vaccines, to achieve HIV eradication.
Using Direct Analysis
of Bioreactor Harvest for Clone
Selection and Process Optimization Therapeutic monoclonal
antibodies (MAbs) mostly are manufactured using bioengineered mammalian cells cultured in a bioreactor for two to three weeks.
Iterative cycles
of hypermutation and
selection continue until
antibodies of high antigen binding specificity emerge (affinity maturation).
Antibodies are raised in a
selection of host species and directed against a wide variety
of species and Ig regions.
The flexibility and customizability
of the new indirect EasySep ™ Release Positive
Selection Kits enable researchers to use
antibodies directed to virtually any targets
of their choice.
Thanks to the generous sponsorship
of Maria Bonino, and the design genius
of Magda Becerra catvirus.com can now proudly introduce a
selection of beautiful posters with the key message: «If you intend to get a purebred kitten, have him or her tested for FCoV
antibodies BEFORE you buy.»
ACT - activated clotting time (bleeding disorders) ACTH - adrenocorticotropic hormone (adrenal gland function) Ag - antigen test for proteins specific to a disease causing organism or virus Alb - albumin (liver, kidney and intestinal disorders) Alk - Phos, ALP alkaline phosphatase (liver and adrenal disorders) Allergy Testing intradermal or blood
antibody test for allergen hypersensitivity ALT - alanine aminotransferase (liver disorder) Amyl - amylase enzyme — non specific (pancreatitis) ANA - antinuclear
antibody (systemic lupus erythematosus) Anaplasmosis Anaplasma spp. (tick - borne rickettsial disease) APTT - activated partial thromboplastin time (blood clotting ability) AST - aspartate aminotransferase (muscle and liver disorders) Band band cell — type
of white blood cell Baso basophil — type
of white blood cell Bile Acids digestive acids produced in the liver and stored in the gall bladder (liver function) Bili bilirubin (bile pigment responsible for jaundice from liver disease or RBC destruction) BP - blood pressure measurement BUN - blood urea nitrogen (kidney and liver function) Bx biopsy C & S aerobic / anaerobic bacterial culture and antibiotic sensitivity test (infection, drug
selection) Ca +2 calcium ion — unbound calcium (parathyroid gland function) CBC - complete blood count (all circulating cells) Chol cholesterol (liver, thyroid disorders) CK, CPK creatine [phospho] kinase (muscle disease, heart disease) Cl - chloride ion — unbound chloride (hydration, blood pH) CO2 - carbon dioxide (blood pH) Contrast Radiograph x-ray image using injected radiopaque contrast media Cortisol hormone produced by the adrenal glands (adrenal gland function) Coomb's anti- red blood cell
antibody test (immune - mediated hemolytic anemia) Crea creatinine (kidney function) CRT - capillary refill time (blood pressure, tissue perfusion) DTM - dermatophyte test medium (ringworm — dermatophytosis) EEG - electroencephalogram (brain function, epilepsy) Ehrlichia Ehrlichia spp. (tick - borne rickettsial disease) EKG, ECG - electrok [c] ardiogram (electrical heart activity, heart arryhthmia) Eos eosinophil — type
of white blood cell Fecal, flotation, direct intestinal parasite exam FeLV Feline Leukemia Virus test FIA Feline Infectious Anemia: aka Feline Hemotrophic Mycoplasma, Haemobartonella felis test FIV Feline Immunodeficiency Virus test Fluorescein Stain fluorescein stain uptake
of cornea (corneal ulceration) fT4, fT4ed, freeT4ed thyroxine hormone unbound by protein measured by equilibrium dialysis (thyroid function) GGT gamma - glutamyltranferase (liver disorders) Glob globulin (liver, immune system) Glu blood or urine glucose (diabetes mellitus) Gran granulocytes — subgroup
of white blood cells Hb, Hgb hemoglobin — iron rich protein bound to red blood cells that carries oxygen (anemia, red cell mass) HCO3 - bicarbonate ion (blood pH) HCT, PCV, MHCT hematocrit, packed - cell volume, microhematocrit (hemoconcentration, dehydration, anemia) K + potassium ion — unbound potassium (kidney disorders, adrenal gland disorders) Lipa lipase enzyme — non specific (pancreatitis) LYME Borrelia spp. (tick - borne rickettsial disease) Lymph lymphocyte — type
of white blood cell MCHC mean corpuscular hemoglobin concentration (anemia, iron deficiency) MCV mean corpuscular volume — average red cell size (anemia, iron deficiency) Mg +2 magnesium ion — unbound magnesium (diabetes, parathyroid function, malnutrition) MHCT, HCT, PCV microhematocrit, hematocrit, packed - cell volume (hemoconcentration, dehydration, anemia) MIC minimum inhibitory concentration — part
of the C&S that determines antimicrobial
selection Mono monocyte — type
of white blood cell MRI magnetic resonance imaging (advanced tissue imaging) Na + sodium ion — unbound sodium (dehydration, adrenal gland disease) nRBC nucleated red blood cell — immature red blood cell (bone marrow damage, lead toxicity) PCV, HCT, MHCT packed - cell volume, hematocrit, microhematocrit (hemoconcentration, dehydration, anemia) PE physical examination pH urine pH (urinary tract infection, urolithiasis) Phos phosphorus (kidney disorders, ketoacidosis, parathyroid function) PLI pancreatic lipase immunoreactivity (pancreatitis) PLT platelet — cells involved in clotting (bleeding disorders) PT prothrombin time (bleeding disorders) PTH parathyroid hormone, parathormone (parathyroid function) Radiograph x-ray image RBC red blood cell count (anemia) REL Rocky Mountain Spotted Fever / Ehrlichia / Lyme combination test Retic reticulocyte — immature red blood cell (regenerative vs. non-regenerative anemia) RMSF Rocky Mountain Spotted Fever SAP serum alkaline phosphatase (liver disorders) Schirmer Tear Test tear production test (keratoconjunctivitis sicca — dry eye,) Seg segmented neutrophil — type
of white blood cell USG Urine specific gravity (urine concentration, kidney function) spec cPL specific canine pancreatic lipase (pancreatitis)-- replaces the PLI test spec fPL specific feline pancreatic lipase (pancreatitis)-- replaces the PLI test T4 thyroxine hormone — total (thyroid gland function) TLI trypsin - like immunoreactivity (exocrine pancreatic insufficiency) TP total protein (hydration, liver disorders) TPR temperature / pulse / respirations (physical exam vital signs) Trig triglycerides (fat metabolism, liver disorders) TSH thyroid stimulating hormone (thyroid gland function) UA urinalysis (kidney function, urinary tract infection, diabetes) Urine Cortisol - Crea Ratio urine cortisol - creatine ratio (screening test for adrenal gland disease) Urine Protein - Crea Ratio urine protein - creatinine ratio (kidney disorders) VWF VonWillebrands factor (bleeding disorder) WBC white blood cell count (infection, inflammation, bone marrow suppression)