Scientists who are in the process of developing prototypes for potential new anticancer agents that
selectively kill tumor cells by interfering with the regulation of intracellular pH, have found that alkaline treatments do NOT have the desired effect - but strongly acidic treatments do.13
Similarly, it may be possible to identify and validate new targets for drugs that would
selectively kill tumor cells with a particular molecular context.
Iodine 131 is a radioactive isotope that
selectively kills the tumor cells, sparing the healthy tissue.
Not exact matches
Traditional genetic approaches together with the new wealth of genomic information for both human and model organisms open up strategies by which drugs can be profiled for their ability to
selectively kill cells in a molecular context that matches those found in
tumors.
Rather than target a
tumor - suppressor gene directly, Ideker and team took the approach of identifying genetic interactions between a
tumor suppressor gene and another gene, such that simultaneous disruption of both genes
selectively kills cancer
cells.
Led by Ludwig Lausanne investigator Alexandre Harari and George Coukos, director of the Ludwig Institute for Cancer Research, Lausanne, the study shows that ovarian
tumors harbor highly reactive killer T
cells — which
kill infected and cancerous
cells — and demonstrates how they can be identified and
selectively grown for use in personalized,
cell - based immunotherapies.
Researchers at Oregon State University have developed a new way to
selectively insert compounds into cancer
cells — a system that will help surgeons identify malignant tissues and then, in combination with phototherapy,
kill any remaining cancer
cells after a
tumor is removed.