The Horch lab previously correlated upregulation of sema2a — the gene that codes for a diffusible
semaphorin protein in invertebrates — with this compensatory growth.
Polleux F., Morrow T. and Ghosh A. (2000)
Semaphorin 3A is a chemoattractant for cortical apical dendrites.
Polleux F., Giger R.J., Ginty, D.D. Kolodkin A.L. and Ghosh A. (1998) Patterning of cortical efferent projections
by semaphorin - neuropilin interactions.
Dennis Zambrano: Characterization of
Semaphorins 1a and 2a in the Developing Embryo of the Cricket Gryllus bimaculatus (Advisor: H. Horch)
Lucia Saidenber: Investigating the Role of
Semaphorin 2a in Dendritic Plasticity Following Deafferentation in the Auditory System of the Adult Cricket
Adam Zhang»14 Quantifying Changes in
Semaphorin Expression after Deafferentation in Gryllus Bimaculatus read a summary of the project»
The other finding was of a variant near genes for several so -
called semaphorins, proteins that guide developing nerve cells as they grow toward their final targets.
Motoneuronal Sema3C is essential for setting stereotyped motor tract positioning in limb - derived
chemotropic Semaphorins.
Daniel Hetherman: Morphological consequences of
semaphorin knockdown on compensatory dendritic sprouting in the cricket, Gryllus bimaculatus
Elizabeth Sheldon - The role of
semaphorin as a molecular guidance cue for dendritic regeneration in the cricket auditory system
Katherine Gribble: Expression of the guidance
factor semaphorin 2a in the cricket Gryllus bimaculatus following denervation
4) Squeezing Axons Out of the Gray Matter: A Role for Slit and
Semaphorin Proteins from Midline and Ventral Spinal Cord.
Monique Lillis: Effects of the downregulation of
semaphorin 1a and 2a on the auditory system of Gryllus bimaculatus (Advisor: H. Horch)
Rohit Sangal: Investigation of the Differential Expression
of Semaphorin - 2a due to Deafferentation in the Cricket, Gryllus bimaculatus
«It looks like
the semaphorin variant doesn't by itself lead to Hirschsprung's, but when there's a variant in Ret too, it causes the pathway to malfunction and can cause disease,» Chakravarti says.
Through studies in mice and zebrafish, the researchers found that
the semaphorins are indeed active in the developing enteric nervous system, and that they interact with Ret in a system of signals called a pathway.
Commissural axon navigation: Control of midline crossing in the vertebrate spinal cord by
the semaphorin 3B signaling.
Semaphorins are a class of proteins that have been shown to play a role in dendritic growth in a wide variety of species, working as either a chemoattractant or chemorepellant in guiding growth of dendrites during development.
Ketura Berry: Investigating the causative role of
semaphorin - 2a in compensatory growth in the cricket Gryllus bimaculatus
One,
semaphorin - 4a (Sema4a), is carried on the surface of various immune cells that can spark inflammation.
Isabel Low: Characterization of
semaphorin in the central nervous system of adult crickets following deafferentation
GSC co-option of core developmental pathways, including
the Semaphorin, Notch and Wnt pathways.
We have identified that GSCs preferentially re-activate
the Semaphorin - Neuropilin - Plexin axonal guidance program.