Sentences with phrase «semi-starved lean mice»

«How obesity dulls the sense of taste: Obese mice had about 25 percent fewer taste buds than lean mice in study.»

Scientists reached this conclusion by transferring microbes from bypass - treated obese mice to a group of lean mice raised in sterile conditions that left them with no intestinal bacteria at all.

In another animal microbiome experiment, Jeffrey Gordon, a biologist at Washington University in St. Louis, took a suite of microbes from the guts of both obese and lean mice and transplanted them into the guts of microbe - free mice.

These mice lived just as long as semi-starved lean mice, even though they had at least four times the body fat of normal mice.

«The nondigestible compounds in the Granny Smith apples actually changed the proportions of fecal bacteria from obese mice to be similar to that of lean mice,» Noratto said.

«Importantly, we found that blocking the actions of the endocannabinoids with pharmacological inhibitors of cannabinoid receptors in the periphery completely normalized food intake and meal patterns in western diet - induced obese mice to levels found in control lean mice fed standard chow.»

Protective antibodies from lean mice also failed to protect obese mice from flu infections.

«This is the first study to show that current strategies to bolster the effectiveness of flu vaccines protected lean mice from serious illness but fell short of protecting obese mice from infections,» said corresponding author Stacey Schultz - Cherry, Ph.D., a member of the St. Jude Department of Infectious Diseases.

In addition, lean mice who received vaccines with adjuvants were protected from severe flu infections.

Moreover, obese - phenotype mice were invaded by members of the Bacteroidales from the lean mice, but, happily, the lean animals resisted invasion by the obese microbiota.

To explore that question, a team led by Cornell University biomedical engineer Claudia Fischbach first showed that female mice that were obese, because of genetics or a high - fat diet, had more fibrous mammary fat pads with straighter collagen fibers than those seen in lean mice (see image).

Our results indicate that the percentage of macrophages in the adipose tissue that surrounds and infiltrates the extensor digitalis longus muscle is increased in obese mice compared with lean mice.

We estimate that the percentage of macrophages in adipose tissue ranges from under 10 % in lean mice and humans to over 50 % in extremely obese, leptin - deficient mice and nearly 40 % in obese humans.

Adipose tissue within muscle contained significant numbers of F4 / 80 + macrophages, and the percentage of F4 / 80 + cells within this adipose tissue was markedly increased in obese mice compared with lean mice (41 % ± 4 % of macrophages vs. 12 % ± 2 % of macrophages, respectively; P < 0.005, mean ± SD)(Figure 4).

Calibration mark = 40 0m; white bars, lean mice; gray bars, Lepob / ob mice.

Macrophages in the adipose tissue of lean mice were uniformly small, isolated, and widely dispersed among the adipocytes.

The percentage of F4 / 80 - positive macrophages within this adipose tissue was markedly increased in obese compared with lean mice (e, P < 0.005).

The scientists found that obese mice had more harmful bacteria in their guts compared to lean mice, which caused inflammation throughout their bodies, leading to very rapid joint deterioration.

The knee cartilage of obese mice who ate the oligofructose supplement was indistinguishable from that of the lean mice.

While IRAB - A produced a decrease in blood glucose in lean mice, the data in DIO mice indicated an exacerbation of insulin resistance; these data were unexpected and suggested the interplay of complex unknown pharmacology.

After exercising for six weeks, both obese and lean mice showed a significant reduction in the overall size of fat cells and the overall amount fat in the marrow.

In the overweight mice, there was a significant weight lose after eight weeks, but the case was not the same with the lean mice.

Other studies have revealed that lean mice didn't gain as much weight when a high fat diet is supplemented with green tea.

Transplanting gut flora from obese mice into lean mice turned the formerly lean mice fatter... Compelling evidence that gut flora has an important connection to body fat levels.

Their procedure involved infecting mice without microbiota with either microbiota of obese or lean mice.

Astonishingly, when germ - free mice are colonized with the gut microbiota from genetically obese mice (ob / ob), the otherwise lean mice dramatically increase body weight.

In the second group, they colonized the intestines with flora from a lean mouse.

Other studies have demonstrated that microbes implanted from lean mice into overweight mice caused the mice to lose weight.

Not exact matches

To find out what was going on in the microbiomes of four sets of differently shaped identical twins, researchers transferred some gut bacteria from a lean (human) twin to a sterile mouse: one with no foreign bacteria at all.

The mouse stayed lean, even when they later added some bacteria from the obese twin.

A second and rather unexpected effect was that the mice were lean.

As such, the altered metabolism in the bone cells caused the mice to have a beneficial whole - body glucose turnover and a lean body.

Validating their theory, the research team discovered that SR8278 increased lean mass and muscle function and decreased muscle fibrosis and muscle protein degradation in mice.

The mice that received the microbiomes of the obese mice gained significantly more weight than did the mice with the lean - mouse microbiomes.

In the mice that consumed either type of tea extract, there was less of the type of bacteria associated with obesity and more of the bacteria associated with lean body mass.

She leaned her curly head over his car seat, tickled his toes and cooed like a pro — in a voice squeakier than Mickey Mouse's.

In this study, he exposed lean, brown - furred female mice to 50 milligrams of BPA per kilogram of body weight daily, and the next generation was transformed: More of them were fat, with blond fur.

Maratos - Flier's lab hopes to explore whether obese mice given the hormone will get lean again.

The obese mice seemed more susceptible to the virus, which remained elevated following vaccination compared to blood levels in lean animals.

Researchers looked at the immune response to vaccination in lean and obese mice, including how vaccine dose and different adjuvants impacted that response.

While adjuvants improved the immune response to vaccinations in both lean and obese mice, the overall immune response was reduced in the obese animals compared to their lean counterparts.

Separate groups of germfree mice were colonized with uncultured fecal microbiota from each member of four twin pairs discordant for obesity or with culture collections from an obese (Ob) or lean (Ln) co-twin.

Next, they reduced the blood aP2 levels in obese and diabetic mice to low levels seen in lean healthy mice.

Cohousing mice harboring an obese twin's microbiota (Ob) with mice containing the lean co-twin's microbiota (Ln) prevented the development of increased body mass and obesity - associated metabolic phenotypes in Ob cage mates.

In an attempt to increase sensitivity for sepsis, Canaan aged these FAT10 knockout mice and made the discovery that mice lacking the gene were lean and aged more slowly.

By comparing the behavior of XBP - 1s in the obese mice with that in lean, healthy ones, he discovered an inflammatory protein that modifies XBP - 1s in healthy animals so it can be shuttled into the nucleus.

Their study showed that mice without the Y6 gene were smaller, and had less lean tissue, than normal mice.

The second image shows a mouse that has propped his nestlet against a wall, forming a makeshift lean - to.

«The mice also lost lean muscle mass.

Associate Professor Amanda Sainsbury - Salis expressed surprise at the impact of the Y6 gene deletion on mice, commenting «I find it amazing that one gene, which is expressed in the small part of the brain that controls the body clock, has such a profound impact on how much fat is stored on the body, and how much lean tissue is maintained.»