Sentences with phrase «senescent cells in culture»

They showed that rapamycin reduced the secretion of inflammatory cytokines from senescent cells in culture and in mice by suppressing the mTOR pathway, which promotes growth.

Not exact matches

Oisín has shown as much as an 80 % reduction in senescent cells in cell culture and significant reductions of senescent cell burden in naturally aged mice.

The most well - known of these are so - called «senescent» cells, originally characterized by Leonard Hayflick as mitotic cells that reached growth arrest after a limited replicative lifespan (later associated with telomere attrition) under unphysiological conditions in culture.

Consistent with their previous studies in cell culture, mice exposed to paraquat under realistic conditions developed an increased burden of senescent cells in their brains (Figure 1, (a-c)-RRB--- and this plague was almost entirely restricted to astrocytes (Figure 1 (d)-RRB-.

And sure enough, this increased burden of senescent cells caused the same problems in living mice as in the researchers» cell culture experiments, as well as in previous work in paraquat - exposed mice.

Oisín's platform has shown as much as an 80 % reduction in senescent cells in cell culture and significant reductions of senescent cell burden in naturally aged mice.

After initial testing demonstrated that their senoablative constructs could eliminate up to 80 % of senescent cells in cell culture, the Oisín team tested them out in living mice, showing that it can purge senescent cells from multiple tissues in middle - aged animals.