Sentences with phrase «senescent cells levels»

Not exact matches

David Frescas et al (2017) Murine mesenchymal cells that express elevated levels of the CDK inhibitor p16 (Ink4a) in vivo are not necessarily senescent (http://www.tandfonline.com/doi/full/10.1080/15384101.2017.1339850)

(6) However, it would be useful to see a more thorough analysis of the effect of ablating p16Ink4a - expressing senescent cells, and whether there may instead be evidence of a short - term rejuvenation of tissue function that is slowly lost over time to rising levels of other kinds of aging damage that INK - ATTAC activation does not address.

(6) Following this initial test of abrogating the early, age - related rise in p16Ink4a - expressing cell burden, the investigators probed the effects of leaving BubR1H / H; INK - ATTAC to undergo 5 months of rapid «premature aging» (and thus, to the attendant accumulation of high levels of p16Ink4a - positive cells and onset of «early - aging» phenotypes), and only then inducing ablation of senescent cells with the INK - ATTAC drug - activated system (see Figure 2 (g) below).

Dr. Campisi has found instead that a minority of senescent cells evade destruction by secreting high levels of matrix metalloproteinases (MMPs), which cleave MICA / B ligands and thereby prevent NKG2D binding.

Rather, the defective checkpoint system was left to proceed, and one of its downstream consequences, which was still under normal regulation — and one known to be directly induced by the normal degenerative aging process — was reversed at the structural level, by clearing out the p16Ink4a - positive senescent cells that had accumulated to an abnormal degree in their tissues.