«Exhausted T cells display a variety of functional defects,» says Nicholas Haining, BM, BCH, of Dana - Farber / Boston Children's,
senior author of the new paper.
«Bioengineers are like nature's detectives, searching for clues in patterns of DNA to help solve the mysteries of genetic diseases,» says Patrick Hsu, a Helmsley - Salk Fellow and
senior author of the new paper.
«A lot of diabetes in the elderly goes undiagnosed because they don't have the classical risk factors for type 2 diabetes, such as obesity,» says Evans, director of Salk's Gene Expression Laboratory and
senior author of the new paper, which was published November 18, 2015 in Nature.
«These spores are like armored seeds, and they can pass through the gut's acidic environment intact,» says Philip Hanna, Ph.D.,
senior author of the new paper and a professor of microbiology and immunology at U-M.
«We knew that food pantries, in North Carolina and many other states, aren't regulated the same way that restaurants are, and that pantries are crucial distributors of food to those in need, but we did not have a good understanding of how food safety is practiced at food pantries,» says Ben Chapman, an associate professor of youth, family, and consumer sciences at NC State and
senior author of a new paper on the work.
«Almost all life on Earth is based on plants — animals eat plants and we eat animals or plants,» says Wolfgang Busch, an associate professor in Salk's Plant Molecular and Cellular Biology Laboratory and
senior author of the new paper.
«Colobops would have been a diminutive but plucky little beast, part of a little - known menagerie of small animals that lived among the first dinosaurs,» said Bhart - Anjan Bhullar, assistant professor and assistant curator in geology and geophysics at Yale, and
senior author of a new paper about the discovery in the journal Nature Communications.
«We had some indication that rapamycin would enhance the cytotoxic T cell effect, from previous experiments in both animals and humans showing that the drug produced modest effects by itself,» says Maria Castro, Ph.D.,
senior author of the new paper.
Zhang was
senior author of the new paper along with Michael Graetzel of Switzerland's École Polytechnique Fédérale de Lausanne.
With E. coli gaining resistance to the antibiotics that many women take to treat UTIs, or prevent recurring ones, the search for a vaccine takes on new urgency, says Harry Mobley, Ph.D.,
senior author of the new paper and chair of the Department of Microbiology and Immunology at U-M.
«Now, we have a mechanism to explain how sequences that comprise one - third of our genome have moved,» says John Moran, Ph.D.,
senior author of the new paper and a longtime U-M and HHMI researcher studying jumping genes.
Then the only option is going back to the ground, or naïve, pluripotent state,» says Yali Dou, Ph.D.,
senior author of the new paper and an associate professor of pathology and biological chemistry at U-M.
«Normally, the immune system will quickly recognize and act upon potential threats such as virally infected cells,» says Axel Nimmerjahn, assistant professor in Salk's Waitt Advanced Biophotonics Center and
senior author of the new paper.
Not exact matches
Palkovacs and graduate student David Fryxell are
senior author and first
author, respectively,
of a
paper on the
new findings published October 21 in Proceedings
of the Royal Society B.
Pentelute is the
senior author of a
paper describing the
new system in the Feb. 27 issue
of Nature Chemical Biology.
Boyden is the
senior author of a
paper describing the
new system in the Proceedings
of the National Academy
of Sciences.
Senior author Dr. Leigh Hochberg — director
of the BrainGate consortium and clinical trial, professor
of engineering at Brown, critical care neurologist at MGH and director
of the V.A. Rehabilitation Research and Development Center for Neurorestoration and Neurotechnology at the PVAMC — agreed that the
new paper is a key advance.
«
New Yorkers tend to focus on rats because they are larger and we see them scurrying around in streets or subways; however, from a public health vantage point, mice are more worrisome because they live indoors and are more likely to contaminate our environment, even if we don't see them,» says
senior author W. Ian Lipkin, MD,
senior author of both
papers, John Snow Professor
of Epidemiology, and director
of CII.
«Any terahertz communications application is going to need some form
of multiplexing and demultiplexing,» said Daniel Mittleman, professor
of engineering at Brown and
senior author of a
paper describing the
new device.
The
new research is a collaboration with Xinshu (Grace) Xiao, the
paper's other
senior author and a UCLA associate professor
of integrative biology and physiology.
Whereas other researchers have built them before, the
new device is the most efficient one yet, says Evelyn Wang, an associate professor
of mechanical engineering at M.I.T. and the
paper's
senior author.
Other
senior authors of the
paper are David Sinclair, a professor at Harvard Medical School and the University
of New South Wales, and Zolt Arany, a professor at the University
of Pennsylvania.
«If you looked at metal under a microscope you'd see that it is composed
of millions
of closely - packed grains,» says Yuntian Zhu, a professor
of materials science and engineering at NC State and
senior author of two
papers on the
new work.
«This really glues together everything we know about J147 in terms
of the link between aging and Alzheimer's,» says Dave Schubert, head
of Salk's Cellular Neurobiology Laboratory and the
senior author on the
new paper.
«Because we have this 24 - hour turnaround time with the
new test, there are veterinary hospitals and clinics that can test and get results rapidly and make sure they are not exposing other animals to Salmonella,» said Belinda Thompson, assistant clinical professor at the Animal Health Diagnostic Center and a
senior author of the
paper.
«In the ongoing arms race between white hats and black hats, researchers and developers are constantly coming up with
new security extensions,» says Dr. William Enck, an assistant professor
of computer science at NC State and a
senior author of a
paper describing the
new framework.
«Our hair follicles are constantly recycling: when a hair falls out, the whole hair follicle has to grow back,» said Michael Rosenblum, MD, PhD, an assistant professor
of dermatology at UCSF and
senior author on the
new paper.
The results
of the study, published in a research article in the journal Nature Medicine, could lead soon to
new treatments for chronic kidney disease that target these risk factors, according to Dr. Jochen Reiser, the
senior author of the
paper.
«We believe that our kirigami - based strategy opens avenues for the design
of a
new class
of soft crawlers,» said Katia Bertoldi, the William and Ami Kuan Danoff Professor
of Applied Mechanics and
senior author of the
paper.
«It's an early result,» says David H. Sachs,
senior author of a
paper describing the work in The
New England Journal
of Medicine.
Stanley W. K. Ng, a
senior PhD candidate in the lab
of Dr. Peter Zandstra at the Institute for Biomaterials and Biomedical Engineering, University
of Toronto and co-lead
author of the
paper, used rigorous statistical approaches to develop and test the
new «stemness score,» using AML patient data provided by the Princess Margaret leukemia clinic and collaborators in the United States and Europe.
Jensen, Myerson, and Timothy Jamison, the head
of MIT's Department
of Chemistry, are the
senior authors of a
paper describing the
new system in the March 31 online edition
of Science.
«There were nearly 80,000
new cases
of bladder cancer and more than 18,000 deaths in 2017,» said George Netto, M.D., a
senior author on the UroSEEK
paper, formerly at The Johns Hopkins University and currently chair
of pathology at the University
of Alabama - Birmingham.
The work described in the
new paper — published December 8, 2017, in Science — was led by three young UCSF researchers: Tomasz Nowakowski, PhD, an assistant professor
of anatomy; Alex Pollen, PhD, an assistant professor
of neurology; and Aparna Bhaduri, PhD, when all three were post-doctoral researchers in the UCSF lab
of Arnold Kriegstein, MD, PhD, the
new paper's
senior author.
According to Andrew Allen, the
senior author on the
paper, the
new research indicates that particular groups
of bacteria, perhaps specifically cultivated by phytoplankton, are also important for regulating the magnitude
of phytoplankton blooms.
«Although sharks are charismatic predators that capture the interest
of many, we still only have a very basic understanding
of their ecological roles in nature,» said Doug Rasher, a
senior research scientist at Bigelow Laboratory and lead
author of the
new paper.
«The ultimate goal is to use these atomic - layer semiconducting thin films to create devices that are extremely flexible, but to do that we need to transfer the thin films from the substrate we used to make it to a flexible substrate,» says Cao, who is
senior author of a
paper on the
new transfer technique.
«This mechanism may offer the potential to develop an entirely
new therapeutic approach,» says C. Ronald Kahn, M.D., Joslin's chief academic officer, Mary K. Iacocca Professor
of Medicine at Harvard Medical School and
senior author of a
paper on the research published in the journal Nature.
«This protein is highly expressed in the nervous system and has an integral role in neuronal development,» said Elizabeth Wilson - Kubalek,
senior staff scientist in Professor Ron Milligan's laboratory at TSRI and co-first
author of the
new paper with Christopher Garnham and Annapurna Vemu
of the NIH's National Institute
of Neurological Disorders and Stroke (NINDS).
«The fossilized flowers provide a
new window into the earliest Paleocene communities in South America, and they are giving us the opportunity to compare the response to the extinction event on different continents,» said Nathan Jud, the
paper's first
author and a postdoctoral researcher in Maria Gandolfo's lab, a
senior research associate at the L.H. Bailey Hortorium and a co-
author of the
paper.
This is the first demonstration
of effective delivery
of antibody mimics into cells, which could allow researchers to develop
new drugs for cancer and many other diseases, says Pentelute, the
senior author of the
paper.
But the
new study firmly establishes that some
of these cells endure for many decades in some Medalists — offering clues to potential treatments for preserving and even restoring the crucial cell population, says George L. King, M.D.,
senior author on the
paper, Joslin's chief scientific officer and head
of the Dianne Nunnally Hoppes Laboratory for Diabetes Complications.
We thought it might be interesting if you could have a relatively simple system that could deliver many different compounds,» says Klavs Jensen, the Warren K. Lewis Professor
of Chemical Engineering, professor
of materials science and engineering, and a
senior author of a
paper describing the
new device in this week's issue
of the Proceedings
of the National Academy
of Sciences.
The work described in the
new paper — published Dec. 8, 2017, in Science — was led by three young UCSF researchers: Tomasz Nowakowski, PhD, an assistant professor
of anatomy; Alex Pollen, PhD, an assistant professor
of neurology; and Aparna Bhaduri, PhD, when all three were post-doctoral researchers in the UCSF lab
of Arnold Kriegstein, MD, PhD, the
new paper's
senior author.
«This adds a
new dimension to head and neck cancer biology that was not on anyone's radar screen before,» said Levi A. Garraway, a
senior associate member
of the Broad Institute, an assistant professor at Dana - Farber Cancer Institute and Harvard Medical School, and a
senior author of one
of the Science
papers.
Kriegstein, the John Bowes distinguished professor in stem cell and tissue biology at UCSF and a member
of the
new Kavli Institute for Fundamental Neuroscience, also at UCSF, is the
senior author of the
paper, published online March 30 in Cell Stem Cell.
«Besides showing a link between the immune system and elevated lipids, this study also opens a
new avenue for the study
of the close and complex link between elevated blood lipid levels and chronic inflammation as manifest in coronary heart disease,» said Fu,
senior author on the
paper.
«We believe this tiny microfabricated device could have tremendous impact in understanding brain diseases, as well as providing
new ways
of delivering biopharmaceuticals and performing biosensing in the brain,» says Robert Langer, the David H. Koch Institute Professor at MIT and one
of the
paper's
senior authors.
«This is an important
new chapter in our ongoing work to understand the mechanisms driving genomic diversity and through that the evolution
of our species,» said Kari Stefansson, CEO
of deCODE and
senior author on the
paper.
«This research opens up an entirely
new set
of questions about the development
of type 2 diabetes,» says Susan Bonner - Weir, a Joslin
Senior Investigator and corresponding
author on a
paper describing the work in the journal Cell Metabolism.