A combination of in vitro, in situ, molecular biology and clinical studies has formed the basis of our knowledge about the taste receptor proteins in the glucose -
sensing enteroendocrine cells and the secretion of incretins by these cells.
Along with intestinal stem cells, the team identified differentiated nutrient - digesting and absorbing enterocytes, mucus - producing Goblet cells, hormone - secreting
enteroendocrine cells, and microbiome - regulating and
sensing Paneth cells, and they performed a series of assays that confirmed their functions.