Implantable spinal cord stimulators and peripheral nerve stimulators designed to interrupt nerve pain impulses were developed more than 30 years ago, but the devices work by interacting with
sensory nerve cells, leading to numbness, tingling and other side effects.
«It appears there is cross-talk between pathways called calcium channels in
sensory nerve cells that process the itch signal.»
Chen's team focused on the dorsal root ganglion of laboratory mice, a structure near the spinal cord that is full of
sensory nerve cells.
After initial infection, HSV enters a latent state in
sensory nerve cells, periodically reactivating to produce disease.
The odorant receptor molecules sit on the surface of
sensory nerve cells in our nose.
That cold tolerance is linked to changes in a specific cold - sensing protein in
the sensory nerve cells of the ground squirrels and another hibernator, the Syrian hamster, researchers report in the Dec. 19 Cell Reports.
Found in
the sensory nerve cells of vertebrates, TRPM8 typically sends a sensation of cold to the brain when activated by low temperatures.
Mishra's team focused on a neurotransmitter called brain natriuretic peptide (BNP), which is expressed in a small number of
sensory nerve cells or neurons.
Not exact matches
Furthermore, dendritic
cells were found to guide the regenerating corneal
sensory nerve fibers after wounding; this association is disrupted in the diabetic corneas.
Dendritic
cells mediate
sensory nerve innervation and regeneration through direct
cell - to -
cell contact and CNTF secretion.
Yu said the impairment of
sensory nerve regeneration in diabetic corneas is due to decreased ciliary neurotrophic factor, as evidenced by the fact that dendritic
cells express ciliary neurotrophic factor (CNTF) in normal and healing corneas but decrease in diabetic corneas due to the reduced infiltration of dendritic
cells.
«What we think happens is that the bacteria activate immune
cells, which release chemicals called cytokines that then act on receptors on the
sensory nerves to increase their activity,» he says.
They first showed that mice with severed
sensory nerves produce excessive BH4, churned out both by the injured
nerve cells themselves and by macrophages — immune
cells that infiltrate damaged
nerves and inflamed tissue.
The results show that the transplanted stem
cells act as a «bridge» which allows injured
sensory nerve fibers to grow into the spinal cord, rebuild functional
nerve connections, and thereby achieve long term restoration of major parts of the lost
sensory functions.
One trillion
nerve cells, from motor neuron to
sensory neuron, purkinje
cell to retinal ganglion
cell, must grow right way and link in the right way if the nervous system is to be more than a senseless scramble.
A Merkel disc consists of a Merkel
cell and a closely associated
nerve ending that branches from a single
sensory nerve.
Such molecular understanding about the
sensory information transmission between Merkel
cells and
nerve endings may lay the foundation to treat the intense pain felt by patients with a gentle touch of their inflamed skin — a pathological pain known as tactile allodynia.
Based on previous studies, researchers have hypothesized that recreational noise exposure might damage the circuitry between
sensory hair
cells in the inner ear and their auditory
nerve targets that deliver information to the brain.
After other researchers reported that bone marrow stem
cell therapy led to a modest but promising 5 percent improvement in the regeneration of
sensory nerve fibers in rats with spinal cord injuries, he performed a critical reality check.
The researchers measured tail response learning to electric shock to determine patterns of aging in both the
nerve cell that senses touch of the tail, called
sensory neurons, and the motor neurons that signal the tail muscle to contract.
During an early clinical trial at the Miami Project last year, researchers took Schwann
cells from an easily accessible
sensory nerve in a patient's leg, grew them in culture and injected them at the point of the spinal cord injury.
The brain researchers observed that
nerve cells in the
sensory cortex that con - nect to distinct brain areas are activated differentially depending on the task to be solved.
In those organs, ion channels in the
cell membrane of
sensory nerve fibers expand as temperature increases.
All modes of
sensory perception are based on communication between
nerve cells.
Implantable prostheses designed to deliver electrical stimuli directly to the auditory
nerve hold considerable promise for people with a type of deafness in which the
sensory hair
cells of the inner ear are damaged
Nerve cells in our sweat glands and blood vessels may constitute an important, previously unrecognized source of
sensory info.
Neuroscientists think that misplaced sensations, called referred pains, arise when
sensory fibers from different parts of the body connect to the same
nerve cells in the spinal cord or brain stem, confusing your brain about which part of your body the message came from.
The evidence from the patients examined by Rice and Bowsher suggests that the
nerve cells also act as an additional
sensory system.
The peripheral nervous system of vertebrate animals includes three kinds of
nerve cells:
sensory neurons, which transmit impulses from
sensory receptor structures to the brain; motor neurons, which innervate the striated, or skeletal, muscles, and autonomic neurons, which regulate the functional activity of the circulatory system, the organs, the glands and the smooth muscles (such as those of the intestine).
British - born Thomas Jessell, Professor of Neuroscience and Howard Hughes Medical Institute Investigator at Columbia University in New York, US, has worked for more than two decades to understand how
nerve cells in the developing spinal cord assemble into the circuits that control
sensory perception and movement.
Each
nerve in mammalian arms and legs contains multiple
sensory neurons (
nerve cells) transmitting pain and other sensations such as touch or feeling to the spinal cord.
At one end, the
nerves reach the skin
cells where they gather
sensory information, and at the other end is the
cell body, which contains the nucleus and the neuron's genetic information.
The epidermis is innervated by free
sensory nerve endings that establish direct contact with skin
cells.
Although Wnts were better known because of their role as morphogens — proteins that pattern bodily structures and determine
cell fates — Zou recently showed how members of the Wnt family served to guide pathfinding axons up and down the spinal cord by attracting or repelling receptors on the growth cones of
sensory or motor
nerves.
British - born Thomas Jessell, Professor of Neuroscience and Howard Hughes Medical Institute Investigator at Columbia University in New York, U.S., has worked for more than two decades to understand how
nerve cells in the developing spinal cord assemble into the circuits that control
sensory perception and movement.
Stained for Futsch (green, segmented
sensory neurons and dispersed
cell bodies in the ventral
nerve cord) and Ank2 - L (magenta, segmented ventral
nerve cord and a subset of
sensory neurons).
From these observations we infer that the metazoan ancestor possessed a complex
sensory system, and many of the molecular requirements for neural development and
nerve cell function.
Thousands of coiled fine - touch mechanoreceptors called Meissner's corpuscles, the most important
sensory component of the foreskin, encapsulated Vater - Pacinian
cells, Merkel's
cells, nociceptors, and branches of the dorsal
nerve and perineal
nerve.
Because mast
cells are often found near
sensory nerve endings, chronic mast
cell degranulation — which produces a variety of pro-inflammatory and pain enhancing substances — could play a role in many pain disorders including pelvic pain, sciatic pain, headache, postsurgical pain, CRPS, fibromyalgia, and ME / CFS.
Once the virus enters the cat's body, it replicates in the
cells of the muscles and then spreads to the closest
nerve fibers, including all peripheral,
sensory and motor
nerves, traveling from there to the CNS via fluid within the
nerves.