Sentences with phrase «sequence multiple cells»

Nonetheless, it's crucial to sequence multiple cells before trying to identify variants.

Not exact matches

That's why most single - cell DNA sequencing now relies on multiple displacement amplification (MDA).

The need to compare multiple cells» DNA sequences to distinguish genuine genetic variants from artifacts limits some of the potential of single - cell sequencing.

HM - SNS allows researchers to sequence the genomes of single tumor cells and study multiple cells simultaneously, both lowering the cost and boosting data analysis for such studies.

The new study looked at DNA sequences, RNA sequences and proteomes — meaning all of the proteins encoded in a particularly cell or tissue — of multiple cephalopod species to determine how common RNA editing really is.

His team discovered these special sequences are distributed throughout the human genome, embedded in multiple genes as shown in the study in Cell Cycle.

They sequenced the complete genomes of multiple regions in each tumour and looked at which mutations were present in all cells and all regions of each tumour, and which were present in just some.

The transmission of different states of gene expression through multiple cell divisions and across generations has been termed «epigenetic,» since the underlying DNA sequence is identical in both states.

For this compilation, I've emphasized publications in which whole - genome or exome sequencing was employed to multiple tumors or cancer cell lines, with the goal of identifying significantly altered genes or pathways in malignant cells.

For example, during T - cell development genes encoding the TRB molecules are assembled from multiple polymorphic gene segments that undergo rearrangements and selection, generating Vb — Db — Jb combinations that are unique in both length and sequence.

More than half of mammalian genes generate multiple messenger RNA isoforms that differ in their 3 ′ untranslated regions (3 ′ UTRs) and therefore in regulatory sequences, often associated with cell proliferation and cancer; however, the mechanisms coordinating alternative 3 ′ - UTR processing for specific mRNA populations remain poorly defined.

Preliminary FACs screening was performed to remove obvious multiple - cell derived clones which led to the selection of 45 clones for sequencing.

Other uses of having a known link between multiple DNA sequencing reads includes studies of structural variations in for instance cancer cells, and when linking functional genes to taxonomic groups in microbial communities.

A team of computational biologists has developed an algorithm that can «align» multiple sequencing datasets with single - cell resolution.